海南人咀嚼槟榔引起的口腔鳞状细胞癌ceRNA网络分析  

Identifcation of miRNA,lncRNA and mRNA-associated ceRNA networks and potential biomarker for oral squamous cell carcinoma with betel quid chewing in Hainan

作　　者：朱乔[1] 邵小钧[2] 甯超学 赵亚力[1] ZHU Qiao;SHAO Xiaojun;NING Chaoxue;ZHAO Yali(Central Laboratory,Hainan Hospital of PLA General Hospital,Hainan Sanya 572000,China;Stomatology Department,Hainan Hospital of PLA General Hospital,Hainan Sanya 572000,China)

机构地区：[1]解放军总医院海南医院中心实验室,海南三亚572000 [2]解放军总医院海南医院口腔科,海南三亚572000

出　　处：《现代肿瘤医学》2021年第4期573-579,共7页Journal of Modern Oncology

基　　金：三亚市医疗卫生科技创新项目(编号:2017YW23)。

摘　　要：目的:构建咀嚼槟榔引起的口腔鳞状细胞癌(OSCC)的ceRNA网络,探究其表达异常可能影响的调节通路改变。方法:对咀嚼槟榔的OSCC及癌旁组织进行miRNA测序和lncRNA微阵列分析,并建立了ceRNA网络。结果:lncRNA-miRNA-mRNA网络由308个lncRNA,41个miRNA和115个mRNA组成。结论:GO和KEGG分析表明,ceRNA网络参与了MAPK、凋亡、p53和PI3K/Akt等不同的信号通路。Objective:To construct the ceRNA network of oral squamous cell carcinoma(OSCC)induced by betel quid(BQ),and to explore the changes of regulatory pathways that may be affected by abnormal expression ceRNA.Methods:OSCC patients with BQ chewing were involved in this study and participants acted as their own control.MicroRNA sequencing and lncRNA microarray analysis were done.Subsequently,we established the ceRNA network.Results:ceRNA network was conducted in OSCC with BQ chewing.The lncRNA-miRNA-mRNA network was formed by 308 lncRNAs,41 miRNAs and 115 mRNAs.Conclusion:GO and KEGG analysis showed that the network involved in different signal pathways,such as the MAPK,apoptosis,p53 and PI3K/Akt signaling pathway.

关 键 词：槟榔 口腔鳞状细胞癌 ceRNA 海南 

分 类 号：R739.8[医药卫生—肿瘤]