基于大津法的自衰减校正PET图像重建技术在^(18)F-AV45显像中的应用  

Application of OTSU-based self-attenuation correction PET reconstruction technology in ^(18)F-AV45 imaging

作　　者：史新冲[1] 闫礼飞 郑一帆 易畅[1] 罗淦华 张博 张祥松[1] Shi Xinchong;Yan Lifei;Zheng Yifan;Yi Chang;Luo Ganhua;Zhang Bo;Zhang Xiangsong(Department of Nuclear Medicine,the First Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510080,China;Department of Neurology,the First Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510080,China;Raysolution Digital Medical Imaging Company Limited,Ezhou 436000,China)

机构地区：[1]中山大学附属第一医院核医学科,广州510080 [2]中山大学附属第一医院神经科,广州510080 [3]湖北锐世数字医学影像科技有限公司,鄂州436000

出　　处：《中华核医学与分子影像杂志》2021年第1期18-22,共5页Chinese Journal of Nuclear Medicine and Molecular Imaging

基　　金：广东省科技计划(2017B020210001)。

摘　　要：目的探索基于大津法的自衰减校正PET(sacPET)重建技术在^(18)F-florbetapir(AV45)显像中的应用。方法2018年11月到2019年12月间在中山大学附属第一医院前瞻性招募7例确诊的阿尔茨海默病(AD)患者[男4例,女3例,年龄(69.6±4.5)岁]和3名健康对照者(HC)[男1名,女2名,年龄(68.0±4.6)岁]行^(18)F-AV45 PET显像,利用PET采集的原始数据进行sacPET重建。通过视觉分析和半定量分析技术将sacPET数据与标准PET数据进行对比。采用Fisher确切概率法、Kappa检验和Pearson相关分析数据。结果HC组和AD组中,sacPET图像和标准PET图像的放射性分布大致相似,HC者sacPET图像的灰质、白质对比度弱于标准PET图像,而AD患者的sacPET图像上皮质高摄取区域范围小于标准PET图像。视觉分析显示在所有的受试者中,sacPET图像示阳性区域19个,标准PET示阳性区域22个,各脑区的阳性率在2种PET图像间差异无统计学意义(均P>0.05),各个脑区显像结果的总体一致性为88.00%[44/50;Kappa=0.75(95%CI:0.57~0.94),P<0.05]。半定量分析显示,sacPET图像所得到的额叶与扣带回标准摄取值比值(SUVR)低于标准PET图像(0.93±0.06与0.96±0.06和0.99±0.04与1.01±0.04;t值:5.30和5.10,均P<0.01),而顶叶、颞叶和枕叶所得SUVR值高于标准PET图像(0.78±0.08与0.68±0.07、0.97±0.07与0.91±0.08和0.94±0.11与0.71±0.12;t值:6.27、7.36和16.90,均P<0.01);2种PET图像大脑皮质SUVR相关性有统计学意义(r=0.75,P<0.001)。结论在^(18)F-AV45显像中,sacPET重建技术无需CT扫描即可得到可靠有效的PET数据,但其准确性和精度仍有待提高。Objective To explore the application of OTSU-based self-attenuation correction PET(sacPET)reconstruction technology in ^(18)F-florbetapir(AV45)imaging.Methods From November 2018 to December 2019,7 confirmed Alzheimer′s disease(AD)patients(4 males,3 females,age(69.6±4.5)years)and 3 healthy controls(HC;1 male,2 females,age(68.0±4.6)years)were recruited prospectively for ^(18)F-AV45 PET imaging in the First Affiliated Hospital of Sun Yat-Sen University.Original data collected by PET acquisition was processed with sacPET reconstruction and then compared with standard PET images by visual analysis and semi-quantitative analysis.Fisher exact test,Kappa test and Pearson correlation analysis were used to analyze data.Results In HC group and AD group,the radioactive distribution showed by sacPET images and that by standard PET images were similar,and the contrast of gray-white matter in sacPET images was weaker than that in standard PET images.Moreover,the positive uptake area of the cortex in the AD group was smaller than that in standard PET images.Visual analysis showed 19 positive regions in sacPET images and 22 in standard PET images,with no statistical difference of positive rates of the sub-regions in the cortex between the two PET images(all P>0.05),and the overall consistency of 88.00%(44/50;Kappa=0.75(95%CI:0.57-0.94),P<0.05).Semi-quantitative analysis showed that the standardized uptake value ratio(SUVR)of frontal lobe and cingulate gyrus measured by sacPET was lower than that measured by standard PET(0.93±0.06 vs 0.96±0.06 and 0.99±0.04 vs 1.01±0.04;t values:5.30 and 5.10,both P<0.01),while SUVR of parietal lobe,temporal lobe and occipital lobe measured by sacPET was higher than that measured by standard PET(0.78±0.08 vs 0.68±0.07,0.97±0.07 vs 0.91±0.08 and 0.94±0.11 vs 0.71±0.12;t values:6.27,7.36 and 16.90,all P<0.01).The overall SUVR of sacPET images was significantly correlated with the standard PET images(r=0.75,P<0.001).Conclusion For ^(18)F-AV45 imaging,sacPET reconstruction technology can

关 键 词：阿尔茨海默病 淀粉样蛋白 乙二醇类 正电子发射断层显像术 

分 类 号：R749.16[医药卫生—神经病学与精神病学] R817.4[医药卫生—临床医学]