rh-aFGF治疗DM合并胆管结石的疗效及发生感染的logistics分析  

Logistics analysis of the efficacy of rh-aFGF in the treatment of DM with bile duct stones and infections

作　　者：董韶华 孙伟[1] 刘小娜 唐华玲 彭冀[1] DONG Shaohua;SUN Wei;LIU Xiaona;TANG Hualing;PENG Ji(Department of General Surgery,the Second Affiliated Hospital of Xingtai Medical College,Xingtai,Hebei 054000,China)

机构地区：[1]邢台医学高等专科学校第二附属医院普外科,河北邢台054000

出　　处：《重庆医学》2021年第3期453-456,共4页Chongqing medicine

基　　金：河北省邢台市科技计划项目(2018ZC203)。

摘　　要：目的研究重组人酸性成纤维细胞生长因子(rh-aFGF)治疗对糖尿病(DM)合并胆管结石的疗效。方法选取2016年5月至2019年6月该院收治的120例DM合并胆管结石患者为研究对象,分为对照组及观察组,两组均行腹腔镜下经胆囊管开口微切开胆管并一期缝合胆管术(LTCBDE)术,观察组联合使用rh-aFGF治疗。比较两组临床疗效、创面愈合时间和愈合率,统计分析感染发生情况,并采用logistics分析发生感染的影响因素。结果观察组创面愈合时间、感染发生率明显低于对照组,而各时间点的创面愈合率明显高于对照组(P<0.05)。logistics分析显示术中出血量、手术时间、术前空腹血糖、术前糖化血红蛋白是术后感染的危险因素(P<0.05)。结论rh-aFGF治疗DM合并胆管结石可明显降低感染发生率。Objective To analyze the effects of recombinant human acidic fibroblast growth factor(rh-aFGF)on the treatment of diabetes mellitus(DM)complicated with bile duct stones.Methods A total of 120 patients with DM complicated with bile duct stones were selected from may 2016 to june 2019,and divided into the control group and the observation group.Laparoscopic transcystic common bile duct exploration(LTCBDE)was performed in both groups,and rh-aFGF was used in the observation group.The clinical efficacy,wound healing time and healing rate of the two groups were compared,the incidence of infection was analyzed statistically,and the influencing factors of infection were analyzed by logistic analysis.Results The wound healing time and infection rate in the observation group were significantly lower than those in the control group,while the wound healing rate of each time point was significantly higher than that in the control group(P<0.05).Logistic analysis showed that intraoperative bleeding,operative time,fasting blood glucose and glycosylated hemoglobin were the risk factors for postoperative infection(P<0.05).Conclusion rh-aFGF can accelerate wound healing in patients with DM complicated with bile duct stones and reduce the postoperative infection.

关 键 词：腹腔镜检查 消化系统外科手术 成纤维细胞生长因子1 糖尿病 胆石 伤口愈合 感染 

分 类 号：R575.7[医药卫生—消化系统]