肝积方加味联合还原型谷胱甘肽在晚期原发性肝癌肝郁脾虚兼血瘀证患者姑息性治疗中的应用  

Application of Reduced Glutathione Combined with Modified Ganji Prescription in Palliative Treatment for Patients with Advanced Primary Liver Cancer of Liver-stagnation Spleen-deficiency and Blood-stasis Syndromes

作　　者：孙经纬[1] 邵铭[1] SUN Jingwei;SHAO Ming(Jiangsu Provincial Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Traditional Chinese Medicine,Nanjing Jiangsu 210029,China)

机构地区：[1]南京中医药大学附属江苏省中医院,江苏南京210029

出　　处：《四川中医》2020年第12期109-112,共4页Journal of Sichuan of Traditional Chinese Medicine

基　　金：江苏省中医药局科研项目(编号:YB2015101)。

摘　　要：目的:观察肝积方加味联合还原型谷胱甘肽在晚期原发性肝癌肝郁脾虚兼血瘀证患者姑息性治疗中的应用效果。方法选取2016年9月~2019年9月海南省第二人民医院收治的晚期原发性肝癌肝郁脾虚兼血瘀证患者80例,随机数表法将患者分为观察组和对照组,每组各40例。对照组给予还原型谷胱甘肽+对症支持治疗,观察组在对照组的基础上采用肝积方加味治疗,连续治疗两个月后比较两组患者的近期疗效、血小板参数、肝功能指标及生活质量等。结果:治疗后,观察组的临床症状改善率为64.50%高于对照组的42.50%,总生活质量评分为(148.41±18.47)分高于对照组的(139.58±19.33)分,差异有统计学意义(P<0.05);治疗后,观察组的PDW与MPV水平低于对照组,ALT、AST与TBIL水平高于对照组,差异有统计学意义(P<0.05)。结论:肝积方加味联合还原型谷胱甘肽活血汤能有效缓解原发性肝癌肝郁脾虚兼血瘀证患者的临床症状,改善患者血小板水平与肝功能,提高生活质量,值得临床推广与应用。Objective: To explore the application effect of Reduced Glutathione(GSH) combined with Modified Ganji Prescription in palliative treatment for patients with advanced primary liver cancer(PLC) of liver-stagnation spleen-deficiency and blood-stasis syndrome.Methods: Eighty patients with advanced PLC of liver-stagnation spleen-deficiency and blood-stasis syndrome who were admitted to Hainan Second People’s Hospital from September 2016 to September 2019 were enrolled.They were divided into observation group and controlled group by the random number table method, 40 cases in each group.The controlled group was given GSH and symptomatic supportive treatment, while the observation group was given MODIFIED Ganji Prescription on basis of the controlled group.After 2-month continuous treatment, short-term curative effect, platelet parameters, liver function indexes and quality of life were compared between the two groups.Results: After treatment, the improvement rate of clinical symptoms in the observation group was higher than that in the controlle group(64.50% vs 42.50%),and the total score of quality of life was higher than that in the controlled group [(148.41±18.47) points vs(139.58±19.33) points](P < 0.05).After treatment, levels of PDW and MPV in the observation group were lower than those in the controlled group, while levels of ALT,AST and TBIL were higher than those in the controlled group(P < 0.05).Conclusion: GSH combined with Modified Ganji Prescription can effectively alleviate clinical symptoms, improve platelet level and liver function, and improve quality of life in patients with PLC of liver-stagnation spleen-deficiency and blood stasis syndrome.

关 键 词：原发性肝癌 晚期 肝积方 肝郁脾虚证 姑息性治疗 

分 类 号：R735.7[医药卫生—肿瘤]