消化内镜氩离子凝固术后不同黏膜保护剂应用的对比研究  

Comparative study of different mucosal protective agents after endoscopic argon plasma coagulation

作　　者：赵明星[1] 朱玉侠[1] 孔祥云[1] 姜登鸽 张丽秋 靳斌[1] 路伟[1] 李蓉[1] 张雪丽[1] 张永红[1] ZHAO Mingxing;ZHU Yuxia;KONG Xiangyun;JIANG Dengge;ZHANG Liqiu;JIN Bin;LU Wei;LI Rong;ZHANG Xueli;ZHANG Yonghong(Department of Gastroenterology,the First Hospital of Xi’an,Xi’an,710002,China)

机构地区：[1]西安市第一医院消化内科,西安710002

出　　处：《中国中西医结合消化杂志》2021年第1期24-27,共4页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

摘　　要：目的:探讨不同黏膜保护剂在上消化道黏膜隆起病变内镜下氩离子凝固术后的临床应用效果。方法:选取西安市第一医院2018年6月-2020年6月行内镜下氩离子凝固术的240例患者,术后随机分为A、B、C、D组,每组60例。A组单独使用PPI制剂泮托拉唑;B组使用康复新液+泮托拉唑;C组使用硫糖铝混悬凝胶+泮托拉唑;D组使用胶体果胶铋颗粒+泮托拉唑。术后4周复查胃镜观察创面愈合情况,评价临床疗效,观察药物不良反应。结果:术后4周,4组创面糜烂或溃疡性病变愈合有效率分别为90.00%、98.33%、85.00%、96.67%,B组与D组明显优于A组、C组(P<0.05);4组临床症状缓解有效率分别为81.70%、98.33%、86.70%、90.00%,B组及D组总有效率明显高于A组与C组,差异有统计学意义(P<0.05);A、B、C、D组患者不良反应发生率分别为15.00%、1.60%、16.67%、6.67%,B组与D组不良反应发生率明显低于A组和C组,差异有统计学意义(P<0.05)。结论:康复新液联合PPI制剂在上消化道内镜氩离子凝固术后应用可以提高创面愈合有效率、快速缓解临床症状、减少不良反应发生率,为内镜下治疗术后的优选方案,值得临床推广应用。Objective:To investigate the clinical effect of different mucosal protectors in the endoscopic argon plasma coagulation of upper gastrointestinal mucosal protrusion.Methods:A total of 240 patients with undergoing endoscopic therapy in the First Hospital of Xi’an from June 2018 to June 2020 were randomly divided into group A(n=60),B(n=60),group C(n=60)and group D(n=60).The group A was given pantoprazole;group B was given Kangfuxin liquid and pantoprazole;group C was given sucralfate Gel and pantoprazole;group D was given colloidal bismuth pectin granules and pantoprazole.The differences on the healing of mucosal injury after 4 weeks,and the clinical symptom remission rate,and adverse event rate were compared on the four groups.Results:The effective rate of wound erosion or ulcer healing was 90.00%,98.33%,85.00%,96.67%in the four group,with the healing recovery and degree of B group and D group was higher than A group and C group after 4 weeks(P<0.05).The effective rates of clinical symptom relief were 81.70%,98.33%,86.70%and 90.00%respectively,the clinical symptom remission rate in group B and D group was higher than that in A and C group(P<0.05).The incidence of adverse reactions in group A,B,C and D were 15.00%,1.60%,16.67%and 6.67%,respectively,the adverse effects of the group B and D was lower than A group and C group(P<0.05).Conclusion:Kangfuxin liquid combined with PPI preparation can improve the wound healing efficiency,quickly relieve clinical symptoms and reduce the incidence of adverse reactions.It is the best scheme for clinical treatment after endoscopic treatment,and is worthy of clinical application.

关 键 词：黏膜保护剂 质子泵抑制剂 内镜氩离子凝固术 

分 类 号：R573[医药卫生—消化系统]