丁苯酞联合阿司匹林及氯吡格雷对进展性脑梗死患者凝血功能及脑血流动力学的影响  

Effects of Butylphthalide Combined with Aspirin and Clopidogrel on Blood Coagulation Function and Cerebral Hemodynamics in Patients with Progressive Cerebral Infarction

作　　者：刘保茹[1] 周江朝[2] Liu Baoru;Zhou Jiangchao(Department of Neurology,No.1 Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000;Department of Neurosurgery,No.1 Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000)

机构地区：[1]河南科技大学第一附属医院神经内科,洛阳471000 [2]河南科技大学第一附属医院神经外科,洛阳471000

出　　处：《数理医药学杂志》2021年第2期245-247,共3页Journal of Mathematical Medicine

摘　　要：目的:丁苯酞联合阿司匹林及氯吡格雷对进展性脑梗死患者凝血功能及脑血流动力学的影响。方法:采用随机数字表法,将某院2017年2月~2019年3月收治的100例进展性脑梗死患者分为对照组和观察组各50例。两组均采用常规治疗(脱水剂、神经细胞保护剂、钙离子拮抗剂、自由基清除剂及活血化瘀药等),对照组采用阿司匹林及氯吡格雷治疗,观察组在对照组基础上加用丁苯酞治疗,对比两组治疗前后凝血功能及脑血流动力学指标的变化。结果:治疗后,观察组凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血酶时间(APTT)均长于对照组,血浆纤维蛋白原(FIB)低于对照组,差异有统计学意义(P<0.05);观察组治疗后平均血流速度(Vmean)、收缩期峰值血流速度(Vmax)高于对照组,搏动指数(PI)低于对照组,差异有统计学意义(P<0.05)。结论:丁苯酞联合阿司匹林及氯吡格雷可提升进展性脑梗死患者的治疗效果,有效改善凝血功能及脑血流动力学指标。Objective:To investigate the effect of butylphthalide combined with aspirin and clopidogrel on blood coagulation function and cerebral hemodynamics in patients with progressive cerebral infarction.Methods:Using a random number table method,100 patients with progressive cerebral infarction admitted to a hospital from February 2017 to March 2019 were divided into two groups,with 50 cases in each group.Both groups were treated with conventional treatments(dehydrating agents,neuroprotective agents,calcium ion antagonists,free radical scavengers and blood stasis agents,etc.).The control group was treated with aspirin and clopidogrel,and the observation group was treated with butyphthalide on the basis of control group.The changes of blood coagulation function and cerebral hemodynamic indexes before and after treatment were compared between the two groups.Results:After treatment,the prothrombin time(PT),thrombin time(TT)and activated partial thrombin time(APTT)of the observation group were longer than those of the control group,and the plasma fibrinogen(FIB)was lower than that of the control group.The difference was statistically significant(P<0.05).The average blood flow velocity(Vmean)and peak systolic blood flow velocity(Vmax)of the observation group after treatment were higher than those of the control group,and the pulsation index(PI)was lower than that of the control group.The difference was statistically significant(P<0.05).Conclusion:Butylphthalide combined with aspirin and clopidogrel can improve the therapeutic effect of patients with progressive cerebral infarction,and effectively improve blood coagulation function and cerebral hemodynamics.

关 键 词：进展性脑梗死 阿司匹林 氯吡格雷 丁苯酞 凝血功能 脑血流动力学 

分 类 号：R743.3[医药卫生—神经病学与精神病学]