TPX2蛋白在宫颈鳞癌组织中的表达及临床意义  

Expression of TPX2 protein in cervical squamous cell carcinoma and its clinical significance

作　　者：马玉花 姜敏[2] 卡米拉·库来西江 高静 来依宁 刁兆杰[2] 吴叶菊[2] 朱敏 MA Yuhua;JIANG Min;Kamila·Kulaixijiang;GAO Jing;LAI Yining;DIAO Zhaojie;WU Yeju;ZHU Min(Shanghai East Hospital of Tongji University School of Medicine,Shanghai 290001,China;Karamay Central Hosptial of Xinjiang Karamay,Xinjiang 834000,China)

机构地区：[1]同济大学附属东方医院,上海290001 [2]克拉玛依市中心医院,新疆克拉玛依市834000

出　　处：《新疆医学》2021年第1期17-22,共6页Xinjiang Medical Journal

基　　金：克拉玛依市中心医院院级项目(项目编号:YK2019-1)。

摘　　要：目的宫颈鳞状细胞癌最有效的治疗方法之一是根治性同步放化疗(DPP周疗),但是治疗效果却因为治疗抵抗而非常有限。在这项研究中,我们探讨Xklp2靶蛋白(targeting protein for Xklp2,TPX2)表达与宫颈鳞状细胞癌患者临床病理特征和预后的相关性。方法采用免疫组织化学法对2009年1月1日至2012年12月31日在本院初始接受了根治性放射治疗的宫颈鳞癌患者142例的活检组织进行TPX2蛋白检测。结果宫颈鳞癌组织中TPX2的表达与淋巴转移(χ2=11.255,P=0.007),肿瘤大(χ2=7.074,P=0.008),低血红蛋白水平(χ2=5.494,P=0.019)和复发(χ2=27.168,P <0.001)有统计学意义的关联,而与年龄等因素无关联(P> 0.05)。根治性放射治疗近期疗效反应与TPX2表达水平有关联,高表达者放疗效果差(χ2=10.649,P=0.003)。RFS和OS的影响因素有淋巴转移(χ2=10.026,P=0.002;χ2=5.785,P=0.016)、肿瘤大(χ2=9.105,P=0.003;χ2=6.945,P=0.008)、低血红蛋白水平(χ2=8.588,P=0.003;χ2=12.438,P <0.001)、TPX2高表达(χ2=20.848,P <0.001;χ2=14.876,P <0.001),然而RFS和OS的独立不良预后因素只有TPX2高表达[P=0.006,HR=4.016,95%CI(1.502-10.753)]、[P <0.001,HR=4.505,95%CI(1.456-14.085)]。结论 TPX2可能是宫颈鳞癌的放疗疗效和预后估计的一个指标。Objective One of the most effective treatments for cervical squamous cell carcinoma is radical concurrent chemoradiotherapy(DPP), but the therapeutic effect is very limited because of the resistance. In this study, we investigated the correlation between the expression of target protein for xklp2(TPX2) and clinicopathological features and prognosis of cervical squamous cell carcinoma. Methods Immunohistochemical method was used to detect TPX2 protein in 142 patients with cervical squamous cell carcinoma who initially received radical radiotherapy in our hospital from January 1, 2009 to December 31, 2012. Results The expression of TPX2 was significantly correlated with lymph node metastasis(χ~2= 11.255,P = 0.007), tumor size(χ~2= 7.074,P = 0.008), low hemoglobin level (χ~2= 5.494,P = 0.019) and recurrence (χ~2=27.168,P < 0.001), but not with age(P > 0.05). The short-term response to radical radiotherapy was associated with the expression level of TPX2. The patients with high expression of TPX2 had poor radiotherapy effect (χ~2= 10.649,P = 0.003). The influencing factors of RFs and OS were lymph node metastasis (χ~2= 10.026,P =0.002;χ~2= 5.785,P = 0.016), tumor size(χ~2= 9.105,P = 0.003;χ~2= 6.945,P = 0.008), low hemoglobin level(χ~2= 8.588,P = 0.003;χ~2= 12.438,P < 0.001), high expression of TPX2(χ~2= 20.848,P < 0.001;χ~2= 14.876,P < 0.001). However, the only independent adverse prognostic factor of RFs and OS was high expression of TPX2 [P = 0.006,HR = 4.016,95% CI(1.502-10.753)]、[P < 0.001,HR =4.505,95% CI(1.456-14.085)]. Conclusions TPX2 may be an indicator of the efficacy and prognosis of radiotherapy for cervical squamous cell carcinoma.

关 键 词：宫颈鳞癌 TPX2 放射敏感性 预后 

分 类 号：R737.3[医药卫生—肿瘤]