Moderate quantity of lard mixed with sunflower oil attenuate lipid accumulation in mice  

作　　者：Sisi Yan Xin Li Linyu Zhang Yu Zeng Shuiping Liu Xiangyan Liu Huijuan Zhou Lixin Wen Ji Wang 

机构地区：[1]Laboratory of Animal Clinical Toxicology,Department of Clinical Veterinary Medicine,College of Veterinary Medicine,Hunan Agricultural University,Changsha,China [2]Hunan Collaborative Innovation Center of Animal Production Safety,Changsha,China

出　　处：《Oil Crop Science》2020年第4期205-212,共8页中国油料作物学报(英文版）

基　　金：This research was funded by the National Key Research and Development Program of China(2016YDF0501200).

摘　　要：Lard,a fat rich in saturated fatty acids(SFAs),is regarded as a risk factor for metabolic diseases.In the present study,effect of different lard blended with sunflower oil diets on lipid accumulation in adipose tissue,liver,and serum by mouse model was researched.Body weight,body fat percentage,cross-sectional area of adipocytes,liver triglycerides(TGs),and oil red stained area in mice liver of lard blend sunflower oil(L-SFO)group were significantly lower than those of sunflower oil(SFO)group,whereas no significant differences were observed between mice of lard and L-SFO groups.Serum TG and free fatty acid levels were significantly lower in L-SFO group than in other two groups.Furthermore,data showed that sunflower oil decreased contents of hormonesensitive lipase and carnitine palmitoyl transferase 1(CPT-1)and increased fatty acid synthase activity in liver tissue.A mixture of lard and sunflower oil rather than only sunflower oil or lard might promote body fat loss and reduce lipid accumulation in adipose tissue,serum,and liver by promoting hydrolysis of TG,increasingβ-oxidation of fatty acids.These data suggested that mixing lard and vegetable oil(e.g.sunflower oil)for cooking,or alternate using lard and vegetable oil could be beneficial for reducing body fat.

关 键 词：LARD Sunflower oil OBESITY Lipid accumulation Dietary fat 

分 类 号：S853.74[农业科学—临床兽医学]