糖类抗原125、糖类抗原153水平与乳腺癌患者临床特征及预后的关系  

Analysis of the relationship between the expression of carbohydrate antigen 125,carbohydrate antigen 153 and clinical characteristics and prognosis of breast cancer

作　　者：史玲玲[1] 董林[1] 潘滇豫[1] SHI Lingling;DONG Lin;PAN Dianyu(Department of Medical Laboratory,Sanmenxia Central Hospital,Sanmenxia 472000,He’nan,China)

机构地区：[1]三门峡市中心医院医学检验科,河南三门峡4720000

出　　处：《癌症进展》2021年第1期38-41,共4页Oncology Progress

摘　　要：目的探讨糖类抗原125(CA125)、糖类抗原153(CA153)水平与乳腺癌患者临床特征及预后的关系。方法选取220例乳腺癌患者(乳腺癌组)及同期收治的100例健康体检者(健康对照组),比较两组患者血清CA125、CA153水平,比较不同临床特征乳腺癌患者血清CA125、CA153阳性率,并对乳腺癌患者进行为期5年的随访,分析乳腺癌患者预后的影响因素。结果乳腺癌组患者血清CA125、CA153水平均明显高于健康对照组,差异均有统计学意义(P﹤0.01)。临床分期为Ⅲ~Ⅳ期患者的血清CA125、CA153阳性率均高于临床分期为Ⅰ~Ⅱ期的患者,有淋巴结转移患者的血清CA153阳性率高于无淋巴结转移的患者,差异均有统计学意义(P﹤0.05)。CA125、CA153阳性患者平均生存时间均明显短于阴性患者,差异均有统计学意义(P﹤0.01)。临床分期、淋巴结转移、分化程度、CA125及CA153表达情况均是乳腺癌患者预后的独立影响因素。结论乳腺癌患者血清CA125、CA153均存在高水平,不同临床分期、淋巴结转移状态患者阳性率存在差异,且血清CA125、CA153阳性情况与患者预后密切相关。Objective To investigate the relationship between the expression of carbohydrate antigen 125(CA125)and carbohydrate antigen 153(CA153)and the clinical characteristics and prognosis of breast cancer.Method A total of 220 patients with breast cancer(breast cancer group)and 100 healthy subjects(healthy control group)were selected.The levels of serum CA125 and CA153 were compared between the two groups,and the positive rates of serum CA125 and CA153 in patients with breast cancer with different clinical characteristics were compared.Patients with breast cancer were followed up for 5 years to analyze the prognostic factors of breast cancer patients.Result The serum levels of CA125 and CA153 in breast cancer group were significantly higher than those in healthy control group(P<0.01).The positive rates of serum CA125 and CA153 in patients with III-IV stage were significantly higher than those in patients with I-II stage(P<0.05).The positive rate of serum CA153 in patients with lymph node metastasis was significantly higher than that in patients without lymph node metastasis(P<0.05).The average survival time of patients with positive expression of CA125,CA153 were significantly shorter than that of patients with negative expression(P<0.01).Clinical stage,lymph node metastasis,degree of differentiation,expression of CA125 and CA153 were independent prognostic factors of breast cancer.Conclusion CA125 and CA153 are highly expressed in patients with breast cancer,and the positive rate of expression is different in patients with different clinical stages and lymph node metastasis,and the positive expression of serum CA125 and CA153 are closely related to the prognosis of patients.

关 键 词：糖类抗原125 糖类抗原153 乳腺癌 临床特征 预后 

分 类 号：R737.9[医药卫生—肿瘤]