FcγRIIA基因多态性与急性白血病患儿化疗后并发感染的关系  

Relationship of FcγRIIA gene polymorphism with complicated infection after chemotherapy in children with leukemia

作　　者：刘珍 郭青[1] 朱莹莹[2] 苏淑芳[3] 孙晓敏[1] LIU Zhen;GUO Qing;ZHU Yingying;SU Shufang;SUN Xiaomin(Department of General Internal Medicine,the Affiliated Children’s Hospital of Zhengzhou University/He’nan Children’s Hospital/Zhengzhou Children’s Hospital,Zhengzhou 450000,He’nan,China;Department of Hematology Oncology,the Affiliated Children’s Hospital of Zhengzhou University/He’nan Children’s Hospital/Zhengzhou Children’s Hospital,Zhengzhou 450000,He’nan,China;Department of Pediatric Hematology Oncology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,He’nan,China)

机构地区：[1]郑州大学附属儿童医院/河南省儿童医院/郑州儿童医院普内科,郑州4500003 [2]郑州大学附属儿童医院/河南省儿童医院/郑州儿童医院血液肿瘤科,郑州4500003 [3]郑州大学第一附属医院小儿血液肿瘤科,郑州4500000

出　　处：《癌症进展》2021年第1期46-48,共3页Oncology Progress

摘　　要：目的探讨FcγRIIA基因多态性与急性白血病患儿化疗后并发感染的关系。方法根据化疗后是否感染将49例白血病患儿分为感染组(n=28)和未感染组(n=21),分析FcγRIIA基因多态性与化疗后并发感染的关系。结果49例急性白血病患儿中,6例患儿为FcγRIIA-R/H型,17例患儿为FcγRIIA-H型,26例患儿为FcγRIIA-R型。未感染组患儿FcγRIIA-H型的表达频率明显高于感染组,FcγRIIA-R型的表达频率明显低于感染组,差异均有统计学意义(P﹤0.01)。结论FcγRIIA-R型白血病患儿化疗后并发感染的概率较高,可作为白血病患儿化疗后感染的评价指标。Objective To investigate the relationship of Fc gamma RIIA(FcγRIIA)gene polymorphism with complicated infection after chemotherapy in children with leukemia.Method 49 leukemia children were divided into infection group(n=28)and uninfected group(n=21)according to infection or not after chemotherapy,and the relationship of FcγRIIA gene polymorphism with complicated infection after chemotherapy was analyzed.Result 6 patients exhibited FcγRIIA-R/H type,17 patients FcγRIIA-H type and 26 patients FcγRIIA-R type.The frequency of FcγRIIA-H type in uninfected group was significantly higher than that in infection group;the frequency of FcγRIIA-R type in uninfected group was significantly lower than that in infection group,and the differences were statistically significant(P<0.01).Conclusion The incidence rate of complicated infection after chemotherapy in children with FcγRIIA-R type leukemia is significantly increased,which can be used as an evaluation parameter for infection after chemotherapy in children with leukemia.

关 键 词：FcγRIIA 基因多态性 白血病 化疗 感染 

分 类 号：R733.7[医药卫生—肿瘤]