非酒精性脂肪性肝病血清学无创诊断的研究进展  

Progress in serological noninvasive diagnostic methods for non-alcoholic fatty liver disease

作　　者：桑潮 梁丹丹 谢国祥 贾伟[1,2] 陈天璐[1] SANG Chao;LIANG Dan-dan;XIE Guo-xiang;JIA Wei;CHEN Tian-lu(Center for Translational Medicine,Shanghai Sixth People's Hospital,Shanghai Jiao Tong University,Shanghai 200233,China;University of Hawaii Cancer Center,Honolulu 96813,HI,USA)

机构地区：[1]上海交通大学附属第六人民医院转化医学中心,上海200233 [2]夏威夷大学癌症中心,火奴鲁鲁96813

出　　处：《上海交通大学学报（医学版）》2021年第1期112-117,共6页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家自然科学基金(31972935)。

摘　　要：随着肥胖和代谢综合征的流行,非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)已成为我国第一大慢性肝病。NAFLD可从单纯性脂肪肝发展为非酒精性脂肪性肝炎(non-alcoholic steatohepatitis,NASH)、NASH相关肝纤维化和肝硬化,甚至肝细胞癌。准确评估NAFLD并尽早进行干预有利于减轻疾病负担,控制疾病进展。肝穿刺活组织检查是诊断NAFLD的“金标准”,但有一定的局限性和显著的并发症,临床应用受限。血清学检测作为一种无创的检测方法,越来越受到研究者和临床工作者的关注。了解各种NAFLD血清学无创诊断方法和指标的优缺点和应用范围,有助于增加诊断途径、提高诊断效力、降低患者痛苦、节约医疗资源。文章对NAFLD血清学无创诊断研究进展作一综述。Non-alcoholic fatty liver disease(NAFLD)has become the most common chronic liver disease,along with the prevalence of obesity and metabolic syndrome.Non-alcoholic fatty liver will progress to non-alcoholic steatohepatitis(NASH),NASH-related liver fibrosis and liver cirrhosis,and even hepatocellular carcinoma.Accurate assessment and early intervention are conducive to clinical burden reduction and disease control.Although being the"golden standard"for diagnosing NAFLD,the clinical application of liver biopsy is limited due to well-known limitations and significant complications.Serological testing,as a noninvasive method,has been well-recognized among researchers and clinicians.The understanding of the pros and cons and the application ranges of various methods and indexes is helpful for clinical applications,including providing more diagnosis approaches,improving diagnosis power,relieving pain of patients,and saving medical resources.This article reviews the advances in serological noninvasive diagnostic methods for NAFLD.

关 键 词：非酒精性脂肪性肝病 肝脂肪变 脂肪性肝炎 肝纤维化 血清学诊断 

分 类 号：R575[医药卫生—消化系统] R446.1[医药卫生—内科学]