早期负性经历和DNA甲基化对男性性取向的影响  

Effect of adverse childhood experiences and DNA methylation on male sexual orientation

作　　者：付翰林 杨土保[2] 王婷婷[2] 吴肖冰[1] 夏楠[1,2] 冯铁建 FU Hanlin;YANG Tubao;WANG Tingting;WU Xiaobing;XIA Nan;FENG Tiejian(Shenzhen Center for Chronic Disease Control,Shenzhen Guangdong 518020;Xiangya School of Public Health,Central South University,Changsha 410078,China)

机构地区：[1]深圳市慢性病防治中心,广东深圳518020 [2]中南大学湘雅公共卫生学院,长沙410078

出　　处：《中南大学学报（医学版）》2021年第1期91-97,共7页Journal of Central South University ：Medical Science

基　　金：深圳市医疗卫生三名工程(SZSM201611077)。

摘　　要：男性性取向成因复杂,至今尚未明确。近年来,男性性取向成因的生物学研究不断取得新的成果,而环境因素的影响却很少被关注。早期负性经历作为个体发育早期的一种特殊环境,可通过修饰基因DNA甲基化位点,影响个体表型特征。鉴于男性性取向与早期负性经历和DNA甲基化之间的关系,并结合现有理论知识,本文从环境和表观遗传学角度入手,提出"早期负性经历-DNA甲基化-男性性取向"假设,以期为后续研究提供线索。The causes for male sexual orientation are complicated,which have not yet been clarified.Recent years have witnessed fruitful progress in the field of biology,while the impact of environment has received little attention.Adverse childhood experiences(ACEs),identified as a special environment in the early stage of development,can affect the individual phenotype by DNA methylation.Given the relationships among male sexual orientation,ACEs,and DNA methylation,as well as based on the existing theory,this article proposes the model“ACEs-DNA methylation-male sexual orientation”from the perspective of environment and epigenetics,aiming to provide a theoretical basis for future research.

关 键 词：男性性取向 DNA甲基化 早期负性经历 机制 

分 类 号：R394[医药卫生—医学遗传学]