尼莫地平联合胸腺五肽治疗脑出血后缺血性脑损伤效果及其对血清TLR4、RBP4水平的影响  

Effect of the nimodipine combined with thymopentin in the treatment of HIBD,after intracerebral hemorrhage and its effects on serum levels of TLR4 and RBP4

作　　者：薛飞[1] 邱志雄[1] 路楷[1] XUE Fei;QIU Zhi-xiong;LU Kai(Department of Neurosurgery,Jiangyin Hospital of Traditional Chinese Medicine,Jiangyin Jiangsu 214400,China)

机构地区：[1]江苏省江阴市中医院神经外科,214400

出　　处：《蚌埠医学院学报》2021年第1期65-67,共3页Journal of Bengbu Medical College

基　　金：江苏省中医药局科技项目(LB11014);江苏省江阴市社会发展科技计划(2911);江苏省江阴市科技计划项目(Z201506)。

摘　　要：目的:探讨尼莫地平联合胸腺五肽治疗脑出血后缺血性脑损伤效果及其对病人血清Toll样受体4(TLR4)、视黄醇结合蛋白4(RBP4)水平的影响。方法:选取脑出血后缺血性脑损伤病人78例,随机分为观察组和对照组,各39例。对照组给予尼莫地平,观察组给予尼莫地平联合胸腺五肽进行治疗。比较2组病人治疗前和治疗后第15天的脑水肿体积、颅内压、美国国立卫生研究院卒中量表评分、Barthel指数和脑血流动力学指标及血清TLR4、RBP4水平。结果:治疗后,2组病人脑水肿体积、美国国立卫生研究院卒中量表评分、Barthel指数、颅内压水平和血清TLR4、RBP4水平均较治疗前明显改善(P<0.05~P<0.01),且观察组病人以上指标均优于对照组(P<0.05~P<0.01)。治疗后,观察组病人血流动力学指标亦较治疗前明显改善(P<0.01),对照组病人治疗前后血流动力学指标差异无统计学意义(P>0.05)。结论:尼莫地平联合胸腺五肽对于脑出血后缺血性脑损伤病人具有较好治疗效果,并降低病人血清TLR4、RBP4水平,值得临床应用。Objective:To observe the effects of the nimodipine combined with thymopentin in the treatment of hypoxic-ischemic brain damage(HIBD)after intracerebral hemorrhage,and its effect on serum levels of Toll-like receptor 4(TLR4)and retinol binding protein 4(RBP4).Methods:Seventy-eight patients with HIBD after intra cerebral hemorrhage were randomly divided into the observation group and control group(39 cases in each group).The control group was treated with nimodipine,and the observation group was treated with nimodipine combined with thymopentin.The cerebral edema volume,intracranial pressure,national institutes of health stroke scale(NIHSS)score,Barthel index and cerebral hemodynamic index,and serum levels of TLR4 and RBP4 bewteen two groups were compared before and after 15 days of treatment.Results:Compared with before treatment,the cerebral edema volume,NIHSS score,Barthel index,intracranial pressure,and serum levels of TLR4 and RBP4 in two groups were significantly improved after treatment(P<0.05 to P<0.01),and the above indexes in observation group were better than that in control group(P<0.05 to P<0.01).After treatment,the hemodynamic indexes in observation group were significantly improved compared with those before treatment(P<0.01),and the difference of the hemodynamic indexes in control group were not statistically significant between before and after treatment(P>0.05).Conclusions:The nimodipine combined with thymopentin in the treatment of HIBD after intracerebral hemorrhage has good therapeutic effects,and can reduce the serum levels of TLR4 and RBP4,which is worthy of promotion.

关 键 词：缺血性脑损伤 脑出血 尼莫地平 胸腺五肽 TOLL样受体4 视黄醇结合蛋白4 

分 类 号：R743.3[医药卫生—神经病学与精神病学]