扶正祛邪方辅助多西塞他联合顺铂化疗干预中晚期肺癌合并高脂血症的效果及机制  

Effect and Mechanism of Fuzheng Quxie Decoction Supplemented with DP Chemotherapy in Intervention of Patients with Advanced Lung Cancer Complicated with Hyperlipidemia

作　　者：郭鹏[1] 骆莹滨 许荣忠 朱为康[1] 陆俊骏[1] 李雁[1] GUO Peng;LUO Yingbin;XU Rongzhong;ZHU Weikang;LU Junjun;LI Yan(Department of Oncology,Shanghai Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 201103,China)

机构地区：[1]上海中医药大学附属上海市中医医院肿瘤科,上海201103

出　　处：《辽宁中医杂志》2020年第12期136-139,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：上海中医药大学预算内项目(2019LK094)。

摘　　要：目的观察扶正祛邪方辅助多西塞他联合顺铂(DP)化疗干预中晚期肺癌合并高脂血症患者的临床效果,探讨其可能的起效机制。方法选取2017年1月—2019年6月该院收治的中晚期肺癌合并高脂血症患者92例为对象,按照随机数字表法随机分为对照组(n=46)和观察组(n=46)。对照组患者给予DP化疗干预,并给予氟伐他汀钠胶囊睡前口服,20 mg/次,1次/d;观察组患者在对照组基础上加用扶正祛邪方口服,每3周为1个疗程,连续治疗3个疗程。评价肿瘤治疗的近期疗效,观察脂质代谢、红细胞免疫、相关炎症因子指标变化。结果观察组的近期疗效为65.22%(30/46),与对照组的43.48%(20/46)相比显著升高(P <0.05);两组患者治疗后脂质代谢均有所改善,以观察组改善更明显,血脂总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、低密度脂蛋白-C(low-density lipoprotein-C,LDL-C)显著低于对照组,高密度脂蛋-C(high-density lipoprotein-C,HDL-C)水平显著高于对照组(P <0.05);治疗后,观察组的红细胞免疫功能与治疗前相比显著提高,红细胞C3b受体花环率(RBCC3bRR)、红细胞免疫促进因子(RFER)水平较治疗前及对照组明显升高,红细胞免疫复合物花环率(RBC-ICR)、红细胞免疫抑制因子(RFIR)水平则明显降低(P <0.05);而对照组经治疗后红细胞免疫功能较治疗前降低,RBCC3bRR、RFER水平较治疗前及对照组明显降低,RBC-ICR、RFIR水平则明显升高(P <0.05);两组患者治疗后的血清中C反应蛋白(C-reactive protein,CRP)、细胞间黏附分子-1 (ICAM-1)、淋巴细胞功能相关抗原-1 (LFA-1)、同型半胱氨酸(homocysteine,Hcy)等炎症因子水平与治疗前相比均有所降低,观察组显著低于对照组(P <0.05)。结论扶正祛邪方辅助DP化疗干预中晚期肺癌合并高脂血症患者疗效确切,利于改善脂质代谢紊乱状态,提高红细胞免疫功能,初步推断该方法起效与抑制血清中CRP、ICAM-1、LFA-1、HcyObjective To observe the clinical effect of Fuzheng Quxie Decoction supplemented with DP chemotherapy in patients with advanced lung cancer complicated with hyperlipidemia,and explore its possible mechanism of action.Methods A total of 92 patients with advanced lung cancer complicated with hyperlipidemia admitted to our hospital from January 2017 to June 2019 were selected as subjects and randomly divided into a control group( n = 46) and an observation group( n = 46) according to the random number table method.Patients in the control group were given DP chemotherapy intervention and fluvastatin sodium capsules,20 mg/time,1 time/day.On the basis of the control group,the patients in the observation group were treated orally with Fuzheng Quxie Decoction.The short-term efficacy of tumor treatment was evaluated,and changes in lipid metabolism,erythrocyte immunity and related inflammatory factors were observed.Results The short-term efficacy of the observation group was 65.22%( 30/46),which was significantly higher than 43.48%( 20/46) of the control group( P < 0.05).After treatment,lipid metabolism in both groups was improved,so that the improvement was more obvious in the observation group.TC,TG and LDL-C were significantly lower than those in the control group,and HDL-C levels were significantly higher than those in the control group( P <0.05).After treatment,the erythrocyte immune function of the observation group was significantly improved compared with that before treatment.The levels of RBCC3 bRR and RFER were significantly increased compared with those before treatment and those of the control group,while levels of RBCC3 bRR and RFIR were significantly decreased( P < 0.05).However,after treatment,the erythrocyte immune function of the control group was lower than before treatment,levels of RBCC3 bRR and RFER were significantly lower than those before treatment and those of the control group,while the levels of RBCC3 bRR and RFIR were significantly higher( P < 0.05).The serum levels of CRP,ICAM-1,LFA-1 and Hcy i

关 键 词：扶正祛邪方 DP化疗 肺癌 高脂血症 脂质代谢 红细胞免疫功能 炎症因子 

分 类 号：R734.2[医药卫生—肿瘤]