动脉瘤性蛛网膜下腔出血不同手术时机对神经功能和IL-1β及IL-6等水平的影响  

Effects of different surgical timing on neurological function and LEVELS of TNF-α, IL-1, and IL-6 in patients with aneurysmal subarachnoid hemorrhage

作　　者：李东[1] LI Dong(Department of Neurosurgery,the Second Peoples Hospital of Jiaozuo,Jiaozuo,Henan 454000,China)

机构地区：[1]焦作市第二人民医院神经外科,河南焦作454000

出　　处：《医药论坛杂志》2021年第1期59-61,65,共4页Journal of Medical Forum

摘　　要：目的回顾性分析动脉瘤性蛛网膜下腔出血采用不同手术时机治疗对患者血清炎性细胞因子水平和神经功能的影响。方法选取焦作市第二人民医院2014年1月—2019年6月收治的120例动脉瘤性蛛网膜下腔出血患者,根据手术时机不同将75例(发病后<3d)作为观察组,将45例(发病后>3d)作为对照组,均接受动脉瘤颈夹闭手术治疗,比较两组预后、发病后3d和发病后10d血清炎性细胞因子[肿瘤坏死因子(TNF-α)、白介素-1β(IL-1β)、白介素-6(IL-6)]水平及美国国立卫生院神经功能缺损(NIHSS)评分。结果观察组恢复良好率为34.67%,显著高于对照组的11.11%,差异有统计学意义(P<0.05),两组发病后3 d血清TNF-α、IL-6及IL-1β水平差异比较无统计学意义(P>0.05);发病后10d观察组血清炎性细胞因子水平均低于对照组(P<0.05);两组发病后3d NIHSS评分比较差异无统计学意义(P>0.05);两组发病后10d NIHSS评分均低于术前,差异具有统计学意义(P<0.05);观察组发病后10d NIHSS评分与对照组相比,显著降低,差异具有统计学意义(P<0.05)。结论动脉瘤性蛛网膜下腔出血早期手术治疗能够显著提高治疗效果,降低血清炎性细胞因子水平,值得推广。Objective To analyze the effect of different operation time on the nerve function and serum inflammatory cytokine level in patients with aneurysmal subarachnoid hemorrhage. Selection.Methods Our hospital from January 2014 to June 2019 treated 120 cases of patients with aneurysmal subarachnoid hemorrhage, after its attack, according to the operation time will be different(< 3 d) 75 cases as observation group,(after onset > 3 d), 45 patients as control group, were treated with aneurysm neck clip, prognosis, compare two groups after 3 d and incidence after 10 d serum inflammatory cytokine tumor necrosis factor(TNF alpha), interleukin 1 beta(IL-1 beta), interleukin 6(IL-6)level and the national institutes of health neural function defect score(NIHSS).Results The recovery rate in the observation group was 34.67%, significantly higher than that of the control group(11.11%)(P<0.05). The serum inflammatory cytokines level of the observation group was lower than that of the control group 10 days after onset(P<0.05). There was no significant difference in 3 d NIHSS scores between the two groups(P>0.05). The scores of NIHSS at 10 d after onset in both groups were lower than those before operation, and the difference was statistically significant(P<0.05). Compared with the control group, the NIHSS score of the observation group at 10 d after onset was significantly lower(P<0.05).Conclusion Early surgical treatment of aneurysmal subarachnoid hemorrhage can significantly improve the therapeutic effect and reduce the level of serum inflammatory cytokines.

关 键 词：炎性细胞因子 动脉瘤性蛛网膜下腔出血 早期手术 

分 类 号：R743.3[医药卫生—神经病学与精神病学]