甘草酸二铵在肺结核抗结核引起的药物性肝损伤中的应用观察  

Application Observation of Diammonium Glycyrrhizinate in Drug-Induced Liver Injury Caused by Pulmonary Tuberculosis and Anti-Tuberculosis

作　　者：韦永孜 黄丽静[2] 吴波霖 罗淞 Wei Yongzi(Department of Infection,Wuming Hospital,Guangxi Medical University,Nanning Guangxi 530199)

机构地区：[1]广西医科大学附属武鸣医院感染科,广西南宁530199 [2]钦州市第一人民医院感染科,广西钦州535000

出　　处：《黑龙江医药》2021年第1期12-14,共3页Heilongjiang Medicine journal

基　　金：广西壮族自治区卫生和计划委员会自筹经费科研课题(编号:Z20170973)。

摘　　要：目的:探讨甘草酸二铵在肺结核抗结核引起的药物性肝损伤中的应用价值。方法:选取2017年1月至2019年12月就诊于钦州市第一人民医院的肺结核抗结核引起的药物性肝损伤患者80例,按随机数字表法分为两组,各40例。对照组行门冬氨酸钾镁治疗,试验组使用甘草酸二铵治疗。比较两组临床疗效、肝功能指标恢复时间及不良反应发生情况。结果:试验组治疗总有效率高于对照组,血清天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、总胆红素(TBIL)、碱性磷酸酶(AKP)恢复时间短于对照组,差异有统计学意义(P<0.05);试验组不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。结论:甘草酸二铵可有效改善肺结核抗结核引起的药物性肝损伤患者的肝功能,减轻临床症状,安全性较高,值得临床推广。Objective:To explore the application value of diammonium glycyrrhizinate in drug-induced liver injury caused by pulmonary tuberculosis and anti-tuberculosis.Methods:A total of 80 patients with drug-induced liver injury caused by pulmonary tuberculosis and anti-tuberculosis who were admitted to the First People’s Hospital of Qinzhou City from January 2017 to December 2019 were selected and divided into two groups of 40 patients by random number table method.The control group was treated with potassium magnesiumaspartate,and the test group was treated with diammonium glycyrrhizinate.The clinical efficacy,recovery time of liver function indexes and occurrence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the experimental group was higher than that in the control group,and serum aspartate aminotransferase(AST),alanine aminotransferase(ALT),total bilirubin(TBIL),alkaline phosphatase(AKP)recovered The time was shorter than that of the control group,and the difference was statistically significant(P<0.05);compared with the control group,the incidence of adverse reactions in the test group was not statistically significant(P>0.05).Conclusion:Diammonium glycyrrhizinate can effectively improve the liver function of patients with drug-induced liver injury caused by pulmonary tuberculosis and anti-tuberculosis,reduce clinical symptoms,and has high safety,which is worthy of clinical promotion.

关 键 词：药物性肝损伤 肺结核抗结核 甘草酸二铵 门冬氨酸钾镁 

分 类 号：R521[医药卫生—内科学] R575[医药卫生—消化系统]