晚期非小细胞肺癌化疗疗效与治疗前中性粒细胞/淋巴细胞比值的关系  

Relationship between chemotherapy efficacy and neutrophil to lymphocyte ratio in advanced non-small cell lung cancer

作　　者：曹宇华[1] 吕艳茹[1] 蒿艳蓉[1] 莫晓云[2] 冯国生[1] 黄露 陈晓丹[1] 高珊[1] 陆水[1] CAO Yuhua;LYU Yanru;HAO Yanrong;MO Xiaoyun;FENG Guosheng;HUANG Lu;CHEN Xiaodan;GAO Shan;LU Shui(Chemotherapy District One,Clinical Oncology Center,the People’s Hospital of Guangxi Zhuang Autonomous Region,Guangxi Zhuang Autonomous Region,Nanning530021,China;Department of Clinical Research,the People’s Hospital of Guangxi Zhuang Autonomous Region,Guangxi Zhuang Autonomous Region,Nanning530021,China)

机构地区：[1]广西壮族自治区人民医院临床肿瘤中心化疗一区,广西南宁530021 [2]广西壮族自治区人民医院临床科研部,广西南宁530021

出　　处：《中国医药导报》2021年第2期94-97,共4页China Medical Herald

基　　金：广西医疗卫生适宜技术开发与推广应用项目(S2019075);广西壮族自治区卫生和计划生育委员会自筹经费科研课题(Z20180748)。

摘　　要：目的探讨中性粒细胞/淋巴细胞比值(NLR)和晚期非小细胞肺癌(NSCLC)患者化疗效果的关系。方法回顾性分析2016年1月-2020年1月广西壮族自治区人民医院符合入组标准的不能手术的ⅢB期和Ⅳ期的80例NSCLC住院患者。采集治疗前NLR,分析NLR与化疗效果之间的关系。依据治疗效果将患者分为疗效应答组和疗效无应答组。结果单因素分析显示,两组NLR比较,差异有统计学意义(P<0.05)。多因素回归分析显示,NLR为影响化疗效果的独立危险因素(OR>1,P<0.05)。结论NSCLC晚期患者化疗效果与治疗前NLR相关,且低NLR患者化疗效果更好;NLR可能成为进展期及晚期NSCLC患者一线化疗效果的预测指标。Objective To investigate the relationship between the neutrophil to lymphocyte ratio(NLR)and chemotherapy efficacy in advanced non-small cell lung cancer(NSCLC).Methods A retrospective analysis of 80 NSCLC inpatients with inoperable stageⅢB andⅣwho met the enrollment criteria in the People’s Hospital of Guangxi Zhuang Autonomous Region from January 2016 to January 2020.NLR was collected before treatment,and the relationship between NLR and chemotherapy efficacy was analyzed.According to the treatment effect,the patients were divided into the curative effect response group and the curative effect non-response group.Results Univariate analysis showed that there was a statistically significant difference in NLR between the two groups(P<0.05).Multi-factor regression analysis showed that NLR was an independent risk factor affecting the effect of chemotherapy(OR>1,P<0.05).Conclusion The efficacy of chemotherapy is related to pre-treatment NLR,and the chemotherapy efficacy is better in patients with lower NLR.NLR may be an index to predict the efficacy of first-line chemotherapy in advanced NSCLC.

关 键 词：中性粒细胞/淋巴细胞比值 肺癌 化疗 效果 

分 类 号：R734.2[医药卫生—肿瘤]