β-环糊精淫羊藿苷包合物对肝癌细胞体外增殖能力的影响  

Effect of β-Cyclodextrin Icariin Inclusion Complex on Proliferation of Hepatoma Cells in Vitro

作　　者：李灿烨 张嘉嘉 庞裕昌 刘靖[1] LI Canye;ZHANG Jiajia;PANG Yuchang;LIU Jing(School of Stomatology and Medicine,Foshan University,Guangdong Foshan 528000)

机构地区：[1]佛山科学技术学院口腔医学院,广东佛山528000

出　　处：《生物化工》2021年第1期87-89,92,共4页Biological Chemical Engineering

基　　金：佛山市科技创新项目(2017AG100111);2019年度佛山科学技术学院学术基金项目(xsjj20191218)。

摘　　要：目的:研究β-环糊精淫羊藿苷包合物对肝癌细胞SMCC-7721和Hep-G2细胞增殖能力的影响。方法:以不同终浓度的淫羊藿苷和β-环糊精淫羊藿苷包合物分别作用于SMMC-7721和Hep-G2细胞株,CCK8法检测其对SMMC-7721和Hep-G2细胞株的增殖影响。结果:不同剂量的淫羊藿苷和β-环糊精淫羊藿苷包合物对SMMC-7721细胞和Hep-G2细胞均有一定的增殖抑制作用,并呈明显的剂量依赖性,包合物对细胞的抑制效果明显。结论:β-环糊精淫羊藿苷包合物能够有效提高淫羊藿苷抑制SMMC-7721和Hep-G2增殖的能力。To study the effect ofβ-cyclodextrin icariin inclusion compound on the proliferation of liver cancer cells SMCC-7721 and Hep-G2 Methods:The effects of icariin andβ-cyclodextrin icariin on the proliferation of SMMC-7721 and Hep-G2 cell lines were detected by CCK8 method.Results:Different doses of icariin andβ-cyclodextrin icariin inclusion compounds have a certain proliferation inhibitory effect on both SMMC-7721 cells and Hep-G2 cells,and they are dose-dependent.The inhibitory effect of cells is obvious.Conclusion:β-cyclodextrin icariin inclusion compound can effectively improve the ability of icariin to inhibit the proliferation of SMMC-7721 and Hep-G2.

关 键 词：SMCC-7721 Hep-G2 淫羊藿苷 β-环糊精淫羊藿苷包合物 细胞增殖 

分 类 号：R735.7[医药卫生—肿瘤]