Human endogenous retroviruses e An ongoing evolutionary tango  

作　　者：Fei Li 

机构地区：[1]Executive Associate Editor,Genes&Diseases,United States

出　　处：《Genes & Diseases》2015年第3期224-224,共1页基因与疾病（英文）

摘　　要：The interplay between virus and host has been an everlasting evolutionary dance,with some advantageous outcomes,and some not so advantageous outcomes,such as cancer and autoimmunity.It has been well recognized that the intertwinement of retroviral DNA regulatory elements,the remnants of retroviral infections,with the host genome is part of a lasting battle between pathogen replication/reinfection and the host defense.The high mutation rate of retro gene sequences has provided a means for viruses to escape suppression by the host,while also serving as a major driving force in host genome evolution.As an“unintended”consequence,the high mutation rate provides a vast retro-sequence repertoire for the host genome to domesticate to its own benefit,such as by regulating healthy biological processes,while also suppressing the harm.1e3 Endogenous retroviruses(ERV)with their functional open reading frames are rare post-infection legacies within the host genome that are inheritable through the germline.

关 键 词：Evolution EMBRYO Gene regulation HERV-K MUTATION 

分 类 号：R73[医药卫生—肿瘤]