不同铂类化疗方案治疗中晚期食管癌对患者预后的影响  

Effects of Different Platinum Chemotherapy Regimens on the Prognosis of Patients with Advanced Esophageal Cancer

作　　者：姚娟[1] 周文彪[1] YAO Juan;ZHOU Wen-biao(Department of Oncology,Taizhou People's Hospital,Taizhou,Jiangsu Province,225300 China)

机构地区：[1]泰州市人民医院肿瘤科,江苏泰州225300

出　　处：《系统医学》2020年第24期120-122,共3页Systems Medicine

摘　　要：目的探析中晚期食管鳞癌患者应用不同铂类化疗方案治疗对预后的影响。方法对该院2015年1月-2017年4月收治的64例中晚期食管癌患者予以分组研究,其中对照组31例,观察组33例。对照组给予多稀紫杉醇联合顺铂化疗,观察组给予多稀紫杉醇联合奥沙利铂化疗,分析比较两组临床疗效、3年生存率、生存质量。结果针对临床疗效来说,观察组总有效率为69.70%,对照组为41.94%,差异有统计学意义(χ^2=5.006,P<0.05)。观察组3年生存率为54.55%,对照组为25.81%,差异有统计学意义(χ^2=5.437,P<0.05)。在生存质量上,观察组患者日常生活、躯体功能、认知功能、情绪功能、社会功能评分分别为(59.24±3.57)分、(63.03±3.69)分、(72.16±3.54)分、(57.62±3.51)分、(58.37±3.61)分,显著高于对照组的(52.13±3.42)分、(55.67±3.57)分、(65.12±3.48)分、(49.31±3.57)分、(51.12±3.71)分,差异有统计学意义(t=8.130、8.650、8.060、8.940、8.490,P<0.05)。结论中晚期食管鳞癌患者应用含奥沙利铂化疗方案的效果更加确切,有助于延长患者生存期,提高患者生存质量。Objective To explore the effect of different platinum chemotherapy regimens on the prognosis of patients with advanced esophageal squamous cell carcinoma.Methods 64 patients with advanced esophageal cancer admitted to the hospital from January 2015 to April 2017 were studied in groups,including 31 cases in the control group and 33 cases in the observation group.The control group was given docetaxel combined with cisplatin chemotherapy,and the observation group was given docetaxel combined with oxaliplatin chemotherapy.The clinical efficacy,3-year survival rate and quality of life were analyzed and compared between the two groups.Results In terms of clinical efficacy,the total effective rate of the observation group was 69.70%and that of the control group was 41.94%,the difference was statistically significant(χ^2=5.006,P<0.05).The 3-year survival rate of the observation group was 54.55%,and that of the control group was 25.81%,the difference was statistically significant(χ^2=5.437,P<0.05).In terms of quality of life,the scores of daily life,physical function,cognitive function,emotional function,and social function of the observation group were(59.24±3.57)points,(63.03±3.69)points,(72.16±3.54)points,and(57.62±3.51)points,(58.37±3.61)points,significantly higher than(52.13±3.42)points,(55.67±3.57)points,(65.12±3.48)points,(49.31±3.57)points,(51.12±3.71)points of the control group,the difference was statistically significant(t=8.130,8.65,8.060,8.94,8.490,P<0.05).Conclusion The effect of oxaliplatin-containing chemotherapy for patients with advanced esophageal squamous cell carcinoma is more accurate,which helps to prolong the survival time and improve the quality of life of patients.It is worthy of clinical application and promotion.

关 键 词：食管鳞癌 顺铂 多稀紫杉醇 奥沙利铂 临床疗效 生存率 生活质量 

分 类 号：R735[医药卫生—肿瘤]