The molecular pathogenic role of inflammatory stress in dysregulation of lipid homeostasis and hepatic steatosis  

作　　者：Yaxi Chen Zac Varghese Xiong Z.Ruan 

机构地区：[1]Centre for Lipid Research,Key Laboratory of Molecular Biology on Infectious Diseases,Ministry of Education,Chongqing Medical University,Chongqing,China [2]John Moorhead Research Laboratory,Centre for Nephrology,University College London Medical School,Royal Free Campus,London,UK

出　　处：《Genes & Diseases》2014年第1期106-112,共7页基因与疾病（英文）

基　　金：This study was supported by Major State Basic Research Development Program of China(973 Program,NO.2012CB517700&2012CB517500);the National Natural Science Foundation of China(81270493,81270789,81200567 and Key Program,No.81030008,81390354);the Moorhead Trust,the Royal Free Hospital Special Trustees Grant-115 through Dr.Zac Varghese,and Kidney Research UK(RP37/2008).

摘　　要：Non-alcoholic Fatty Liver Disease(NAFLD)is becoming the leading cause of chronic liver injury in developed countries and China.Chronic systemic inflammation plays a decisive role and is fundamental in the progression of NAFLD from simple steatosis(SS)toward higher risk nonalcoholic steatohepatitis(NASH)states.However,the exact mechanisms by which inflammation leading to NASH are incompletely understood.In this review,we focus the role of the cross talk between inflammation and lipid homeostasis on the progression of NAFLD.

关 键 词：Ectopic lipid deposition Inflammation Lipid homeostasis Lipid redistribution Non-alcoholic fatty liver disease 

分 类 号：R57[医药卫生—消化系统]