Widespread haploid-biased gene expression enables sperm-level natural selection  

作　　者：Kunal Bhutani 

机构地区：[1]不详

出　　处：《四川生理科学杂志》2021年第1期27-27,共1页Sichuan Journal of Physiological Sciences

摘　　要：Sperm are haploid,but must be functionally equivalent to distribute alleles equally among progeny.Accordingly,gene products are shared through spermatid cytoplasmic bridges which erase phenotypic differences between individual haploid sperm.Here,we show that a large class of mammalian genes are not completely shared across these bridges.We term these genes"genoinformative markers"(GIMs)and show that a subset can act as selfish genetic elements that spread alleles unevenly through murine,bovine,and human populations.We identify evolutionary pressure to avoid conflict between sperm and somatic function as GIMs are enriched for testis-specific gene expression,paralogs,and isoforms.

关 键 词：BRIDGES enable distribute 

分 类 号：R73[医药卫生—肿瘤]