循环microRNA作为肝细胞癌标志物的研究现状  

Current status of research on circulating microRNAs as diagnostic markers for hepatocellular carcinoma

作　　者：谢惠君 Rashed Nasot 宁勇 高川 XIE Huijun;RASHED Nasot;NING Yong;GAO Chuan(School of Laboratory Medicine,Hubei University of Chinese Medicine,Wuhan 430065,China)

机构地区：[1]湖北中医药大学检验学院,武汉430065

出　　处：《临床肝胆病杂志》2021年第2期448-451,共4页Journal of Clinical Hepatology

基　　金：湖北省“楚天学者计划”资助项目(鄂教师函〔2016〕4号)。

摘　　要：肝细胞癌(HCC)是最常见的原发性肝癌,其高死亡率与当前对HCC的诊断和监测手段不理想密切相关。microRNA(miRNA)在HCC的发生和进展过程中发挥重要作用,其异常表达是HCC病理中的常见现象,且miRNA能被细胞释放到循环血中稳定存在。通过讨论miRNA在HCC中作用的研究进展,提出循环miRNA有望成为HCC早期诊断、监测治疗和评估预后的潜在标志物,并分析了现阶段该潜在标志物在临床验证中所面临的问题。Hepatocellular carcinoma(HCC)is the most common primary liver cancer,and its high mortality rate is closely associated with the unsatisfactory diagnostic and monitoring methods for HCC at present.Some microRNAs(miRNAs)play an important role in the development and progression of HCC,and their abnormal expression is a common phenomenon in HCC pathology;in addition,miRNAs can be released into the circulating blood and remain stable in blood.By reviewing the research advances in the role of miRNAs in HCC,it is pointed out that miRNAs are expected to become potential markers for the early diagnosis,monitoring and treatment,and prognostic evaluation of HCC,and this article also analyzes related issues in the clinical verification of such potential markers.

关 键 词：癌 肝细胞 微RNAS 诊断 

分 类 号：R735.7[医药卫生—肿瘤]