自拟降脂方治疗脂肪肝合并颈动脉粥样硬化疗效观察  

Curative Observation of Using Self-made Jiangzhi Recipe in the Treatment of Fatty Liver Disease Combined with Carotid Atherosclerosis

作　　者：其其格[1] 孙萍 QI Qige;SUN Ping(Department of Acupuncture and Moxibustion,Inner Mongolia Normal U-nitersity Hospital,Hohhot Inner Mongolia 010020,China;Department of Ceriatrics,Inner Mongolin Hospital of TruditionalChinese Medicine,Hohhot Inner Mongolia 010020,China)

机构地区：[1]内蒙古师范大学医院针灸理疗科,内蒙古呼和浩特010020 [2]内蒙古自治区中医医院老年科,内蒙古呼和浩特010020

出　　处：《四川中医》2021年第1期100-103,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:观察自拟降脂方对脂肪肝合并颈动脉粥样硬化患者的治疗效果。方法:选取我院142例非酒精性脂肪肝合并颈动脉粥样硬化患者随机分为对照组和研究组,每组71例。对照组予以阿托伐他汀;研究组予以阿托伐他汀联合降脂方水煎剂。比较两组间临床疗效、肝功能指标、血脂水平、颈动脉超声指标及不良反应发生率。结果:对照组总有效率(76.06%)低于研究组总有效率(88.73%),差异有统计学意义(P<0.05)。与对照组比较,研究组治疗后血清丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)、γ-谷氨酰转移酶(CGT)水平较低,治疗后血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平较低,高密度脂蛋白胆固醇(HDL-C)水平较高,治疗后颈动脉内膜中层厚度(CIMT)、粥样硬化斑块数目及颈动脉斑块Crouse积分较低,差异均有统计学意义(均P<0.05)。治疗过程中,研究组出现的不良反应为恶心呕吐、嗜睡、口干及心动过速,对照组出现的不良反应为恶心、腹泻及肌痛。研究组不良反应发生率为9.86%,对照组不良反应发生率为7.04%,两组间差异无统计学意义(P>0.05)。结论:阿托伐他汀联合降脂方对脂肪肝合并颈动脉粥样硬化患者的治疗效果明显,能有效改善肝功能,调节血脂水平,减轻颈动脉粥样硬化,且安全性较高。Objective: To investigate the effect of Atorvastatin combined with Self-made Jiangzhi Recipe for patients with fatty liver disease and carotid atherosclerosis. Methods: 142 patients with non alcohol fatty liver disease and carotid atherosclerosis were randomly divided into a controlled group and a experiment group, each with 71 cases. The controlled group was treated with Atorvastatin, the experiment group received more with Self-made Jiangzhi Recipe. The clinical efficacy, liver function indexes, blood lipid levels, carotid artery ultrasound indexes, and incidence of adverse reactions were compared between 2 groups. Results: The total effective rate in the controlled group(76.06%) was lower than that in the experiment group(88.73%),the differences was statistically significant(P<0.05). Compared with the controlled group, serum levels of alanine transaminase(ALT),aspartate transaminase(AST),γ-glutamyl transferase(GGT) were higher after treatment in the experiment group, serum levels of total cholesterol(TC),triglyceride(TG) and low density lipoprotein cholesterol(LDL-C) were lower after treatment, high density lipoprotein cholesterol(HDL-C) levels were higher, carotid intima-media thickness(CIMT),number of atherosclerotic plaques and Crouse score of carotid plaques were lower after treatment, the differences were all statistically significant(all P<0.05). In the course of treatment, the adverse reactions in the experiment group were nausea and vomiting, drowsiness, dry mouth and tachycardia, the adverse reactions in the controlled group were nausea, diarrhea and myalgia. The incidence of adverse reactions in the experiment group was 9.86%,and the incidence of adverse reactions in the controlled group was 7.04%,there was no significant difference between the two groups(P>0.05). Conclusion: Atorvastatin combined with Self-made Jiangzhi Recipe is effective in the treatment of patients with fatty liver disease and carotid atherosclerosis, which can effectively improve liver function, regulate blood lipid levels, lie

关 键 词：脂肪肝 颈动脉粥样硬化 阿托伐他汀 降脂方 临床疗效 

分 类 号：R575.5[医药卫生—消化系统]