敷和备化方联合TACE术对原发性肝癌患者血清炎性因子及临床疗效观察  

Observation on Serum Inflammatory Factors and Clinical Efficacy of Fuhe Beihua Decoction Combined with TACE in Patients with Primary Liver Cancer

作　　者：蒋锐沅 满婷婷 覃艳春 杨梦娜 莫春梅[2] 荣震[2] JIANG Rui-yuan;MAN Ting-ting;QIN Yan-chun;YANG Meng-na;MO Chun-mei;RONG Zhen(Guangxi Traditional Chinese Medical University,Nanning 530200,China;The first affiliated hospital Guangxi Traditional Chinese Medical University,Nanning 530023,China)

机构地区：[1]广西中医药大学,南宁530000 [2]广西中医药大学第一附属医院,南宁530000

出　　处：《中国中医基础医学杂志》2021年第1期102-106,共5页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家自然科学基金地区基金项目(81760850)-Wnt/β-catenin信号通路介导的敷和备化方对肝癌干细胞作用机制的研究;广西医疗卫生适宜技术开发与推广应用项目(S2018046)-敷和备化方防治原发性肝癌肝动脉化疗栓塞术后复发转移的临床研究;广西中医药大学第一附属医院院内科研项目(2018ZJ004)-敷和备化方的制剂颗粒研究。

摘　　要：目的:探讨敷和备化方联合肝动脉化疗栓塞术(TACE)治疗原发性肝癌患者的临床疗效及对外周血血清炎性因子的调节作用,以期发现敷和备化方治疗原发性肝癌的作用途径。方法:将80例原发性肝癌患者按随机数字表法分为治疗组和对照组,2组均行TACE术治疗,治疗组加用敷和备化方,2组疗程均为4周。比较2组患者治疗前后的近期临床疗效、不良反应、血清甲胎蛋白(AFP)水平、生活质量评分(KPS评分)、中医症状评分和血清炎性因子白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)及肿瘤坏死因子α(TNF-α)的动态变化情况。结果:治疗4周后,治疗组的总有效率、生活质量评分、血清IL-2水平均明显高于对照组,治疗组的不良反应发生率、血清AFP水平、中医症状评分、血清IL-6、IL-8及TNF-α均明显低于对照组,但治疗组的疾病控制率与对照组比较差异无统计学意义。结论:在常规行TACE术治疗原发性肝癌的基础上,加用敷和备化方治疗原发性肝癌的疗效更显著,且上调IL-2和下调IL-6、IL-8、TNF-α等血清炎性因子水平,考虑调节血清炎性因子水平可能是其作用途径之一。Objective:To investigate the clinical efficacy of Fuhe Beihua Decoction combined with hepatic artery chemoembolization(TACE)in the treatment of primary liver cancer patients and its regulatory effect on inflammatory factors in peripheral blood serum,so as to find out the effective approach of Fuhe Beihua Decoction in the treatment of primary liver cancer.Methods:80 patients with primary liver cancer were randomly divided into the treatment group and the control group.Both groups were treated with TACE,and the treatment group was additionally treated with application and preparation formula.The course of treatment for both groups was 4 weeks.The short-term clinical efficacy,adverse reactions,serum alpha-fetoprotein(AFP)level,quality of life score(KPS score),TCM syndrome score and dynamic changes of serum inflammatory factors interleukin-2(IL-2),interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor alpha(TNF-α)before and after treatment were compared between the two groups.Results:After 4 weeks of treatment,the total effective rate,quality of life score and serum IL-2 level of the treatment group were significantly higher than those of the control group.The incidence of adverse reactions,serum AFP level,TCM syndrome score,serum IL-6,IL-8 and TNF-αof the treatment group were significantly lower than those of the control group,but the disease control rate of the treatment group was not significantly different from that of the control group.Conclusion:On the basis of routine TACE treatment of primary liver cancer,the therapeutic effect of applying and preparing prescription is more significant in the treatment of primary liver cancer,and up-regulating IL-2 and down-regulating IL-6,IL-8,TNF-αand other serum inflammatory factors may be one of its action ways.

关 键 词：敷和备化方 肝动脉化疗栓塞术 炎性因子 临床疗效 临床观察 

分 类 号：R735.7[医药卫生—肿瘤]