玻璃体腔注射雷珠单抗联合25G玻璃体切割术治疗糖尿病性视网膜病变的疗效观察  

Efficacy of intravitreal ranibizumab injection combined with 25G vitrectomy in the treatment of diabetic retinopathy:an observation study

作　　者：刘会娟[1] 任芝莉[1] LIU Huijuan;REN Zhili Huadu(District People′s Hospital of Guangzhou,Guangzhou 510800,Guangdong,China)

机构地区：[1]广州市花都区人民医院,广东省广州市510800

出　　处：《微创医学》2020年第6期732-735,共4页Journal of Minimally Invasive Medicine

摘　　要：目的探讨玻璃体腔注射雷珠单抗联合25G玻璃体切割术治疗糖尿病性视网膜病变(DR)的临床效果。方法选取18例(共27只患眼)DR患者,其中采用玻璃体腔注射雷珠单抗联合25G玻璃体切割术治疗的9例(15眼)为观察组,同期接受单纯25G玻璃体切割术治疗,且一般资料与观察组均衡可比的9例(12眼)为对照组。比较两组患者的临床疗效、手术时间、视力、黄斑区视网膜厚度、并发症发生情况等。结果观察组患者的总有效率为93.33%(14/15),高于对照组的50.00%(6/12);观察组手术时间短于对照组;观察组并发症发生率为6.67%(1/15),明显低于对照组的41.67%(5/12);治疗后两组视力均高于治疗前,且观察组高于对照组;治疗后两组黄斑区视网膜厚度均小于治疗前,且观察组小于对照组。以上差异均有统计学意义(均P<0.05)。结论采用玻璃体腔注射雷珠单抗联合25G玻璃体切割术治疗DR的效果显著,能够缩短手术时间,降低并发症发生的风险,值得推广应用。ObjectiveTo investigate the efficacy of intravitreal ranibizumab injection combined with 25G vitrectomy in the treatment of diabetic retinopathy(DR).MethodsEighteen patients(27 eyes in total)with DR were selected;of them,9 cases(15 eyes)treated with intravitreal injection of ranibizumab combined with 25G vitrectomy were enrolled in observation group,and 9 cases(12 eyes)treated with simple 25G vitrectomy during the same period,whose general data were comparable with the observation group,were enrolled in control group.The clinical efficacy,operation time,visual acuity,macular retinal thickness and complications were compared between the two groups.ResultsThe observation group yielded a higher total effective rate[93.33%(14/15)vs.50.00%(6/12)],shorter operation duration,and a lower incidence of complications[6.67%(1/15)vs.41.67%(5/12)]as compared to the control group.After treatment,the visual acuities in both groups were higher than those before treatment,and visual acuity in the observation group was higher than that in the control group.The macular retinal thicknesses of the two groups were smaller than those before treatment,and the thickness of the observation group was smaller than that of the control group.The above differences were statistically significant(all P<0.05).ConclusionIntravitreal injection of ranibizumab combined with 25G vitrectomy has a significant effect on DR,which can shorten the operation duration and reduce the risk of complications.It is worth promoting and applying.

关 键 词：玻璃体腔 雷珠单抗 25G玻璃体切割术 糖尿病性视网膜病变 疗效 

分 类 号：R774[医药卫生—眼科]