降压疗法对缺血性脑出血患者肾功能和预后效果分析  

Effect of Antihypertensive Therapy on Renal Function and Prognosis in Patients with Ischemic Cerebral Hemorrhage

作　　者：寇雨霏 KOU Yufei(Shenzhen Hospital(Guangming),University of Chinese Academy of Sciences,Shenzhen 518107,China)

机构地区：[1]中国科学院大学深圳医院(光明),广东深圳518107

出　　处：《中外医学研究》2021年第2期125-127,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究缺血性脑出血患者采用降压疗法对改善肾功能和疾病预后效果。方法:选择2018年10月-2019年10月在笔者所在医院进行缺血性脑出血治疗的84例患者为研究样本。采取随机数字排列表法将其分成对照组(42例)及观察组(42例),予以对照组甘露醇及依达拉奉注射治疗,予以观察组甘露醇、依达拉奉及甘油果糖治疗。对比两组治疗前后血肌酐及血清胱抑素-C水平、MESSS得分及ADL得分、脑组织水肿体积及血肿体积。结果:治疗前两组血肌酐及血清胱抑素-C水平比较差异无统计学意义(P>0.05),治疗后观察组血肌酐及血清胱抑素-C水平均低于对照组,差异均有统计学意义(P<0.05)。治疗前两组MESSS得分及ADL得分比较差异无统计学意义(P>0.05),治疗后观察组MESSS得分低于对照组,ADL得分高于对照组,差异均有统计学意义(P<0.05)。治疗前两组脑组织水肿体积及血肿体积比较差异无统计学意义(P>0.05),治疗后观察组脑组织水肿体积及血肿体积均小于对照组,差异均有统计学意义(P<0.05)。结论:缺血性脑出血患者采用降压疗法可改善肾功能,改善脑水肿情况,促进血肿吸收,进而保护患者神经功能,提升其日常生活能力,发挥一定临床应用效果。Objective:To explore the effect of antihypertensive therapy on improving renal function and disease prognosis in patients with ischemic cerebral hemorrhage.Method:A total of 84 patients receiving treatment for ischemic cerebral hemorrhage in the author’s hospital from October 2018 to October 2019 were selected as study samples,and the patients were randomly divided into the control group (42 cases) and the observation group (42 cases).Patients in the control group were treated with Mannitol and Edaravone Injection,while patients in the observation group were treated with Mannitol,Edaravone and Glycerol Fructose.The serum creatinine and cystatin C levels,the scores of MESSS and ADL,the cerebral edema volume and hematoma volume before and after treatment were compared.Result:Before treatment,there was no significant difference in serum creatinine and cystatin C levels between the two groups (P>0.05),after treatment,serum creatinine and cystatin C levels in the observation group were lower than those in the control group,the differences were statistically significant (P<0.05).Before treatment,there was no significant difference in the scores of MESSS and ADL between the two groups (P>0.05),after treatment,the MESSS score in the observation group was lower than that in the control group,and the ADL score was higher than that in the control group,the differences were statistically significant (P<0.05).Before treatment,there was no significant difference in the the cerebral edema volume and hematoma volume between the two groups (P>0.05),after treatment,the cerebral edema volume and hematoma volume in the observation group were smaller than those in the control group,the differences were statistically significant (P<0.05).Conclusion:In patients with ischemic cerebral hemorrhage,antihypertensive therapy can improve renal function,improve brain edema,promote the absorption of hematoma,and then protect the neurological function of patients,improve their ability of daily living,and play a certain clinical application eff

关 键 词：缺血性脑出血 降压疗法 肾功能 治疗效果 预后 

分 类 号：R743.3[医药卫生—神经病学与精神病学]