预防性抗生素应用对肝硬化食管胃底静脉曲张破裂出血患者预后效果的研究  

The Prognostic Effect of Prophylactic Antibiotics in Patients with Esophageal and Gastric Varicose Hemorrhage Due to Cirrhosis

作　　者：梁丽燕 严衍伟[1] 陈聪 LIANG Liyan;YAN Yanwei;CHEN Cong(Zhaoqing First People’s Hospital,Zhaoqing 526400,China;不详)

机构地区：[1]肇庆市第一人民医院,广东肇庆526400

出　　处：《中外医学研究》2021年第2期138-140,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨预防性抗生素应用对肝硬化食管胃底静脉曲张破裂出血患者的预后效果。方法:选取笔者所在医院2017年12月-2019年12月收治的肝硬化食管胃底静脉曲张破裂出血患者120例。使用随机数表法将其分为对照组与观察组,各60例。对照组不接受预防性抗生素干预,观察组接受预防性抗生素干预,其余治疗方法均相同。收集两组出血停止时间、输血量、住院天数、住院费用、再出血发生率、院内感染发生率、病死率,进行对比分析。结果:观察组出血停止时间早于对照组,输血量少于对照组,再出血发生率和院内感染发生率均低于对照组,差异均有统计学意义(P<0.05)。两组病死率比较差异无统计学意义(P>0.05)。观察组住院时间短于对照组,住院费用少于对照组,差异均有统计学意义(P<0.05)。结论:对肝硬化食管胃底静脉曲张破裂出血患者预防性应用抗生素,能够缩短患者出血时间,降低院内感染发生率,并减少住院天数及住院费用,帮助患者及家庭减轻负担,具有一定的卫生及社会经济效益,值得临床推广。Objective:To explore the effect of prophylactic antibiotics on the prognosis of patients with esophageal variceal bleeding due to cirrhosis.Method:From December 2017 to December 2019,120 patients with esophageal and gastric varicose vein bleeding due to cirrhosis admitted to the hospital were selected.They were divided into the control group and the observation group,60 cases in each group.The control group received no prophylactic antibiotic intervention,while the observation group received prophylactic antibiotic intervention,and the other treatment methods were the same.The bleeding stop time,blood transfusion volume,hospitalization days,hospitalization expenses,Incidence of rebleeding,Incidence of nosocomial infection and case fatality rate were collected and analyzed.Result:The bleeding stop time in the observation group was earlier than that in the control group,the amount of blood transfusion was less than that in the control group,the incidences of rebleeding and nosocomial infection were both lower than those in the control group,the differences were statistically significant (P<0.05).There was no significant difference in case fatality rate between the two groups (P>0.05).The hospitalization time in the observation group was shorter than that in the control group,hospitalization expenses was less than that in the control group,the differences were statistically significant (P<0.05).Conclusion:The prophylactic application of antibiotics in patients with cirrhosis of esophageal and gastric varices rupture hemorrhage can shorten the time of bleeding,reduce the incidence of nosocomial infection,reduce the length of hospital stay and hospitalization expenses,and help patients and families to reduce the burden,which has certain health and social and economic benefits and is worthy of clinical promotion.

关 键 词：预防性 抗生素 肝硬化 胃底静脉曲张 

分 类 号：R575.2[医药卫生—消化系统]