CYP2B6基因多态性与成年人急性髓系白血病易感性的相关性  

The relationship between the polymorphism of CYP2B6 gene and the susceptibility of acute myeloid leukemia in adults

作　　者：陈宗云 叶晓艺 王若涛 郭建峰 CHEN Zongyun;YE Xiaoyi;WANG Ruotao;GUO Jianfeng(Department of Clinical Laboratory,indong Hospital,Fujian Medical College,Ningde,Fujian 355000,China;Department of Nephrology,Mindong Hospital,Fujian Medical College,Ningde,Fujian 355000,China)

机构地区：[1]福建医科大学附属闽东医院检验科,福建宁德355000 [2]福建医科大学附属闽东医院肾内科,福建宁德355000

出　　处：《国际检验医学杂志》2021年第4期412-415,共4页International Journal of Laboratory Medicine

基　　金：福建省青年科研课题(2017-1-99);宁德市科技计划项目(20160190)。

摘　　要：目的探讨CYP2B6基因多态性与成年人急性髓系白血病(AML)易感性的相关性。方法选取87例首次确诊AML的患者作为AML组,191例健康体检者作为对照组,运用Sanger测序法对CYP2B6785A>G与516G>T两个单核苷酸多态性位点进行基因分型。结果CYP2B6785A>G位点在显性模型下(AG+GG vs.AA,P<0.05,OR=5.34,95%CI:4.05~7.04)和携带等位基因G(G vs.A,P<0.05,OR=2.22,95%CI:1.46~3.37)均会增加患AML的风险。CYP2B6516G>T位点在显性模型下(GT+TT vs.GG:P>0.05,OR=0.70,95%CI:0.41~1.19)和携带等位基因T(G vs.T,P>0.05,OR=0.73,95%CI:0.47~1.15)均与AML患病风险无关。结论CYP2B6785A>G位点携带等位基因G可能会增加AML患病风险。Objective To discuss the susceptibility of gene polymorphism of CYP2B6 to the acute myeloid leukemia(AML)in adults.Methods Using Sanger sequencing technology to identify the genotypes of 785A>G and 516G>T of CYP2B6 in 87 first-diagnosed AMI patients(AMI group),meanwhile 191 healthy volunteers were enrolled as the control group.Results CYP2B6785A>G in the dominant model(AG+GG vs.AA,P<0.05,OR=5.34,95%CI:4.05-7.04)and with allele G(G vs.A,P<0.05,OR=2.22,95%CI:1.46-3.37)both increased the risk of AML.CYP2B6516G>T did not affect the risk of AML in the dominant model(GT+TT vs.GG,P>0.05,OR=0.70,95%CI:0.41-1.19)or with allele T(G vs.T,P>0.05,OR=0.73,95%CI:0.47-1.15).Conclusion CYP2B6785A>G with allele G might increase the risk of AML in adults.

关 键 词：急性髓系白血病 CYP2B6 基因多态性 易感性 

分 类 号：R733.71[医药卫生—肿瘤]