低氧诱导因子-1α与阿尔兹海默症  

Hypoxia Inducible Factor-1αand Alzheimer’s Disease

作　　者：项铭华 詹媛媛 吴刚 徐镇东 王建枝[1,2] 刘蓉 柯丹 王小川[1,2] Xiang Minghua;Zhan Yuanyuan;Wu Gang(Department of Pathophysiology,School of Basic Medicine,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院基础医学院病理生理学系,武汉430030 [2]南通大学神经再生协同创新中心,南通226001

出　　处：《华中科技大学学报（医学版）》2021年第1期123-128,共6页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：国家自然科学基金资助项目(No.31771114)。

摘　　要：阿尔兹海默症(Alzheimer’s disease,AD)是伴有痴呆症的神经性退行性疾病最常见的形式。由β淀粉样蛋白(Aβ)组成的老年斑和由异常过度磷酸化Tau蛋白聚集形成的神经原纤维缠结是AD的两大神经病理学变化。低氧诱导因子-1α(HIF-1α)是缺氧相关病理变化的关键分子。该文综述不同类型缺氧调控HIF-1α及其对AD病理及认知障碍的影响以及作用机制。Alzheimer’s disease(AD)is the most common form of neurodegenerative disease with dementia.Senile plaques composed of amyloid beta protein and neurofibrillary tangles formed by abnormal hyperphosphorylated Tau protein aggregation are two major neuropathological changes in AD.Hypoxia inducible factor-1α(HIF-1α)is a key molecule in hypoxic-related pathological changes.This article reviews how different types of hypoxia modulate HIF-1αand their respective effects on AD pathology and cognitive impairment,as well as its mechanism.

关 键 词：低氧诱导因子-1Α 阿尔兹海默症 Β淀粉样蛋白 TAU蛋白 缺氧 认知功能障碍 

分 类 号：R749.16[医药卫生—神经病学与精神病学]