泌尿生殖系统炎性肌纤维母细胞瘤的临床病理及预后  

Inflammatory myofibroblastic tumors of urogenital system:clinicopathology and prognosis

作　　者：陈波[1] 徐何 郭耀川 郭建兵 柳良仁[1] 魏强[1] CHEN Bo;XU He;GUO Yaochuan;GUO Jianbing;LIU Liangren;WEI Qiang(Department of Urology/Institution of Urology,West China Hospital,Sichuan University,Chengdu 610041;Department of Urology,The Third People's Hospital of Chengdu/The Affiliated Hospital of Southwest Jiaotong University,Chengdu 610014;Department of Urology,Chongqing Three Gorges Central Hospital,Chongqing 404000;Department of Urology,People's Hospital of Shigatse City,Shigatse 857000,China)

机构地区：[1]四川大学华西医院泌尿外科/泌尿外科研究所,四川成都610041 [2]成都市第三人民医院/西南交通大学附属医院泌尿外科,四川成都610014 [3]重庆三峡中心医院,重庆404000 [4]西藏自治区日喀则市人民医院泌尿外科,西藏日喀则857000

出　　处：《现代泌尿外科杂志》2021年第2期112-115,146,共5页Journal of Modern Urology

基　　金：国家自然科学基金(No.81370855,No.81200551,No.81770756);四川省科技厅基金(No.2015SZ0230,No.2017KJT0034;No.2020YJ0054);四川省卫健委项目(No.18PJ462);成都市科技局项目(No.2018-YF05-00208-SN)。

摘　　要：目的研究泌尿生殖系统炎性肌纤维母细胞瘤(IMT)的临床病理特点及患者预后。方法检索四川大学华西医院的医疗记录电子数据库,纳入2009年5月至2019年1月泌尿生殖系统IMT患者共33例,收集并分析了患者的临床特征、病理特征、治疗及预后等资料。结果33例泌尿生殖系统IMT患者的中位年龄为39.5(0~70)岁。最常见的临床表现包括血尿(13例)、疼痛(12例)及肿块(12例),其他临床表现包括排尿困难、尿频、发热等。此外,14例患者出现了贫血,包括10例轻度贫血、4例中度贫血。所有患者均接受了手术切除治疗,术后免疫组化结果提示主要的阳性分子标志物包括SMA(22/25)、MSA(8/9)、CD34(15/17)及CD68(3/3)。术后成功随访患者23例,中位随访时间为78.3(19.2~118.8)个月;随访发现1例患者死于IMT,其余患者均未发现疾病复发或者远处转移。结论总的来说,泌尿生殖系统IMT生物学行为良好,但仍具有复发和远处转移的潜能,术后需密切随访。Objective To investigate the clinicopathological characteristics and prognosis of inflammatory myofibroblastic tumors(IMT)of urogenital system.Methods The medical records databases at West China Hospital of Sichuan University were searched and 33 individuals with IMT treated during May 2009 and Jan.2019 were identified.Baseline clinical characteristics,pathological features,therapy and prognosis were analyzed.Results The median age of patients was 39.5 years(range 0-74 years).The most common manifestations were hematuria(13 cases),pain(12 cases),and mass(12 cases).Other clinical symptoms included dysuria,urinary frequency and fever.Anemia was diagnosed in 14 cases,including 10 mild cases and 4 mo-derate cases.All patients received surgery.The main positive markers of immunohistochemistry staining included SMA(22/25),MSA(8/9),CD34(15/17)and CD68(3/3).Follow-up was available in 23 patients with a median of 78.3 months(range 19.2-118.8 months).No recurrence or metastasis was detected,and 1 patient died of IMT.Conclusion Although favorable prognosis was observed in IMT of urogenital system,close follow-up is still essential.

关 键 词：炎性肌纤维母细胞瘤 泌尿生殖系统 肾脏 膀胱 

分 类 号：R737.1[医药卫生—肿瘤]