成人ADHD患者静息脑电及其与生态执行功能的相关性  

Characteristics of resting state EEG in adults with attention-deficit/hyperactivity disorder and correlations with executive function deficits

作　　者：陈进[1] 李卉[1] 郭晓杰 赵希希 吴占良[1] 钱秋谨[1] 曹庆久[1] 王长明[2] 孙黎[1] 王玉凤[1] CHEN Jin;LI Hui;GUO Xiaojie;ZHAO Xixi;WU Zhanliang;QIAN Qiujin;CAO Qingjiu;WANG Changming;SUN Li;WANG Yufeng(Peking University Sixth Hospital,Peking University Institute of Mental Health,NHC Key Laboratory of Mental Health(Peking U-niversity),National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital),Beijing 100083,China;The National Clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders,Bejing Anding Hospital,Capital Medical University,Beijing 100088,China)

机构地区：[1]北京大学第六医院,北京大学精神卫生研究所,国家卫生健康委员会精神卫生学重点实验室(北京大学),国家精神心理疾病临床医学研究中心(北京大学第六医院),北京100083 [2]首都医科大学附属北京安定医院,国家精神疾病临床研究中心&北京市精神疾病重点实验室,北京100088

出　　处：《中国心理卫生杂志》2021年第3期236-241,共6页Chinese Mental Health Journal

基　　金：国家自然科学基金面上项目(81771479、81971284);十三五科技部重大慢病注意缺陷多动障碍综合干预策略研究(2016YFC1306100);北京市科技计划项目(Z171100001017089);首都卫生发展科研专项项目(首发2020-1-4111)

摘　　要：目的:探究成人注意缺陷多动障碍(ADHD)患者的脑电特征及其与生态执行功能的关系。方法:选取成人ADHD患者33例及正常对照30例,用执行功能行为评定量表成人版(BRIEF-A)评估生态执行功能,并记录静息态脑电,分析不同频段脑电的绝对功率,探讨其与执行功能缺陷的相关性。结果:与正常对照相比,ADHD患者BRIEF-A各因子得分及其全脑θ波及中央区β绝对功率均高于对照组(均P<0.01);ADHD患者的工作记忆评分与其双侧额叶θ波绝对功率呈正相关(r=0.43、0.49,均P<0.05),情感控制评分与双侧中央区β波绝对功率呈正相关(r=0.43、0.49,均P<0.05)。结论:成人ADHD患者生态执行功能存在缺陷,其额叶θ波及中央区-顶叶β波功率增高可能分别参与其工作记忆缺陷及情感控制不良的神经病理学机制。Objective:To explore the characteristics of resting state electroencephalogram(EEG)in adults with attention-deficit hyperactivity disorder(ADHD)and their correlations with executive function deficits.Methods:Totally 33 adults with ADHD and 30 normal controls were selected to evaluate their eco-execu-tive function by the Behavior Rating Inventory of Executive Function(Adult Version,BRIEF-A).The absolute power of EEG at different frequency bands and their correlations with executive function deficits were analyzed.Results:The scores of all factors of ecological executive function and the absolute power ofθwave in whole brain and the absolute power ofβin central region were higher in ADHD group than in the control group(P<0.01).The working memory scores in patients with ADHD were positively correlated with the absolute power of bilateral frontalθwave(r=0.43,0.49,Ps<0.05),the emotional control scores were positively correlated with the absolute power ofβwave in bilateral central regions(r=0.43,0.49,Ps<0.05).Conclusion:It indicates that there are deficits of the ecological executive function in adults with ADHD.The abnormal power ofθwave in frontal lobe andβwave in central parietal lobe of adult ADHD may be involved in the neuropathological mechanism of working memory deficit and poor emotion control respectively.

关 键 词：注意缺陷多动障碍 静息态脑电 生态执行功能 

分 类 号：R749.94[医药卫生—神经病学与精神病学] R741.044[医药卫生—临床医学]