成人ADHD患者脑电α功率不对称性与生态执行功能的相关性  

Relationship between α asymmetry and ecological executive function in adults with attention-deficit/ hyperactivity disorder

作　　者：陈进[1] 赵希希 韩传亮 李卉[1] 吴占良[1] 钱秋谨[1] 曹庆久[1] 王长明[2] 孙黎[1] 王玉凤[1] CHEN Jin;ZHAO Xixi;HAN Chuanliang;LI Hui;WU Zhanliang;QIAN Qiujin;CAO Qingjiu;WANG Changming;SUN Li;WANG Yufeng(Peking University Sixth Hospital,Peking University Instute of Mental Health,NHC Key Laboratory of Mental Health(Peking U-niversity),National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital),Beijing 100083,China;The National Clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders,Beijing Anding Hospi-tal,Capital Medical University,Bejing 100088,China;State Key Laboratory of Cognitive Neuroscience and Learning&IDG/McGovem Instiute for Brain Research,Bejjing Normal University,Bejing 100875,China)

机构地区：[1]北京大学第六医院,北京大学精神卫生研究所,国家卫生健康委员会精神卫生学重点实验室(北京大学),国家精神心理疾病临床医学研究中心(北京大学第六医院),北京100083 [2]首都医科大学附属北京安定医院国家精神疾病临床研究中心&北京市精神疾病重点实验室,北京100088 [3]认知神经科学与学习国家重点实验室/麦戈文脑研究所,北京师范大学,北京100875

出　　处：《中国心理卫生杂志》2021年第3期242-247,共6页Chinese Mental Health Journal

基　　金：国家自然科学基金面上项目(81771479、81971284);十三五科技部重大慢病注意缺陷多动障碍综合干预策略研究.(2016YFC1306100);北京市科技计划项目(Z171100001017089),首都卫生发展科研专项项目(首发2020-1-4111)。

摘　　要：目的:探究成人注意缺陷多动障碍(ADHD)患者静息态脑电α绝对功率不对称性与生态执行功能的相关性。方法:选取成人ADHD患者49例及正常对照45例,用执行功能行为评定量表成人版(BRIEF-A)评估生态执行功能,并记录静息态脑电,分析不同脑区α绝对功率不对称性差异并探讨其与生态执行功能的相关性。结果:ADHD患者双侧额部、前额的α绝对功率不对称性低于正常对照(均P<0.05);成人ADHD在BRIEF-A自评问卷的行为管理指数和元认知指数维度得分均高于对照(均P<0.001);在正常对照中双侧额部(r=0.43,P<0.05)、前额(r=0.43,P<0.05)的α绝对功率不对称性与其自我监控评分呈现正相关,但成人ADHD患者未见此相关性(P>0.05)。结论:成人ADHD患者生态执行功能存在缺陷,额部α绝对功率不对称性与自我监控能力关联性的消失可能是其执行功能受损的神经电生理机制。Objective:To investigate the characteristics of α asymmetry in adults with attention-deficit/hyperactivity disorder(ADHD),and the relationships with ecological executive function(EF).Methods:Forty-nine adults diagnosed with ADHD and 45 normal subjects were recruited.The self-ratings of Behavior Rating Inventory of Executive Function,Adult Version(BRIEF-A) were used to measure the ecological EF.The subjects were recorded with EEG signals during an eye-closed resting-state condition.The absolute power in α band was analyzed,and the α absolute power of different regions and the correlations with ecological executive function were analyzed.Results:The α absolute power asymmetries of frontal and forehead were lower in patients with ADHD than in normal controls(Ps<0.05).The ADHD group showed significantly higher indices ofbehavioral regulation and metacogniton in BRIEF-A than control group(Ps<0.001).In the control group,the α absolute power asymmetries of FP2-FP1(r=0.43,P<0.05) and F4-F3(r=0.43,P<0.05) were positively correlated with the monitor scores,but there was no correlation between the α absolute power asymmetry and EF in adults with ADHD.Conclusion:This study demonstrated the ecological EF deficiencies exist in adults with ADHD,and abnormal frontal α absolute power asymmetry may be involved in the neuropathological mechanism of impaired self-monitor ability of adult ADHD patients.

关 键 词：注意缺陷多动障碍 脑电 α绝对功率不对称性 生态执行功能 

分 类 号：R749.41[医药卫生—神经病学与精神病学] R741.044[医药卫生—临床医学]