Wnt/β-catenin信号通路与肝癌发生发展的研究进展  

Role of Wnt/β-catenin signaling pathway in occurrence and development of hepatocellular carcinoma

作　　者：倪彩菊 覃小珊[2,3] 黄赞松 Cai-Ju Ni;Xiao-Shan Qin;Zan-Song Huang(Graduate School of Youjiang Medical College for Nationalities,Baise 533000,Guangxi Zhuang Autonomous Region,China;Department of Gastroenterology,The Affiliated Hospital of Youjiang Medical College for Nationalities,Baise 533000,Guangxi Zhuang Autonomous Region,China;Guangxi Clinical Research Center for Hepatobiliary Diseases,Baise 533000,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]右江民族医学院研究生学院,广西壮族自治区百色市533000 [2]右江民族医学院附属医院消化内科,广西壮族自治区百色市533000 [3]广西肝胆疾病临床医学研究中心,广西壮族自治区百色市533000

出　　处：《世界华人消化杂志》2021年第4期190-196,共7页World Chinese Journal of Digestology

基　　金：广西自然科学基金资助项目,No.2014GXNSFAA118143;广西科技基地与人才专项(广西肝胆疾病临床医学研究中心研究课题),No.AD17129025;2017年度广西医药卫生自筹经费计划课题,No.Z20170224;广西研究生教育创新计划项目,No.YCSW2020235.

摘　　要：已有研究表明肝癌的发生发展与多种信号通路有关.其中,Wnt配体/β-连环蛋白(Wnt/β-catenin)信号通路参与肝脏疾病进展的所有阶段,从最初的肝损伤到炎症、纤维化、肝硬化以及肿瘤的发生及进展均有所参与.异常的Wnt/β-catenin信号会促进包括癌症在内的不同肝脏疾病的发生和进展.在这篇综述中,我们将在介绍Wnt/β-catenin信号通路的激活、生物学功能及调控机制的基础上,讨论Wnt/β-catenin信号通路在肝癌的发生和进展的中的作用,并将对目前小分子抑制剂、中药提取物及微小RNAs(microRNAs,miRNAs)等能够抑制Wnt/β-catenin信号通路的相关因子进行阐述,为肝癌的基础与临床研究提供参考.Studies have shown that the occurrence and development of liver cancer are related to a variety of signaling pathways.The Wnt/β-catenin signaling pathway is involved in all stages of liver disease progression,from initial liver damage to inflammation,fibrosis,and cirrhosis,as well as the occurrence and progression of tumors.Abnormal Wnt/β-catenin signaling promotes the development and progression of different liver diseases,including cancer.This review introduces the activation,biological function,and regulatory mechanism of the Wnt/β-catenin signaling pathway,discusses the role of ngthis pathway in the occurrence and progression of liver cancer,and describes factors that can inhibit the Wnt/β-catenin signaling pathway,such as small molecule inhibitors,traditional Chinese medicine extracts,and microRNAs,with an aim to provide reference for the basic and clinical research of liver cancer.

关 键 词：肝癌 进展 WNT/Β-CATENIN信号通路 

分 类 号：R735.7[医药卫生—肿瘤]