Animal models of cathartic colon  

作　　者：Yang-Yang Meng Qiao-Dong Li Ya Feng Jie Liu En-Kang Wang Linda Zhong Qiao-Li Sun Jian-Ye Yuan 

机构地区：[1]Institute of Digestive Diseases,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China [2]School of Chinese Medicine,Hong Kong Baptist University,Hong Kong,China

出　　处：《World Journal of Clinical Cases》2021年第6期1251-1258,共8页世界临床病例杂志

基　　金：Supported by Xinglin Scholar,Xinglin Young Talent Program,No.RC-2017-02-07;Shanghai Three-year Action Plan for Accelerating the Development of Traditional Chinese Medicine,No.ZY(2018-2020)-CCCX-2002-01;and Research Fund of Longhua Hospital,No.2018YM05.

摘　　要：The incidence of cathartic colon has been increasing,but satisfactory treatments are still lacking.In order to study the pathological mechanisms of the disorder and identify effective treatment methods,researchers have established different animal models of cathartic colon.This minireview briefly summarizes several common cathartic colon animal models,induced with anthraquinone laxatives such as rhubarb,total anthraquinone,rhein,and emodin,or induced with diphenylmethane laxatives such as phenolphthalein.The advantages and limitations of these models are evaluated and analyzed.We hope that this review will facilitate the selection of suitable models and improve relevant modeling methods.We anticipate the development of more convenient and stable models that can reflect the characteristics of cathartic colon in humans,and serve as useful tools for further studies.

关 键 词：Cathartic colon Animal model LAXATIVE ANTHRAQUINONES DIPHENYLMETHANE CONSTIPATION 

分 类 号：R574.62[医药卫生—消化系统] R-332[医药卫生—内科学]