Effect of alprostadil in the treatment of intensive care unit patients with acute renal injury  

作　　者：Yan Jia Li-Li Liu Ji-Liang Su Xiao-Hua Meng Wei-Xin Wang Cui Tian 

机构地区：[1]Department of Critical Care Medicine,Shandong Taishan Hospital,Tai'an 271000,Shandong Province,China [2]Department of Critical Care Medicine,The Second Affiliated Hospital of Shandong First Medical University,Tai'an 271000,Shandong Province,China

出　　处：《World Journal of Clinical Cases》2021年第6期1284-1292,共9页世界临床病例杂志

摘　　要：BACKGROUND Acute kidney injury(AKI)is a sudden or rapid decline in the filtration function of the kidneys which is marked by increased serum creatinine or blood urea nitrogen.AIM To examine the value of alprostadil-assisted continuous venous-venous hemofiltration(CVVH)in the treatment of severe AKI in severely ill patients.METHODS This was a retrospective study and the inclusion criteria were as follows:(1)Age of patients(≥18 years);(2)Admission to intensive care unit due to non-renal primary disease,APACHE II score(≥18 points);(3)The diagnostic criteria of AKI guidelines were formulated with reference to the Global Organization for the Improvement of Prognosis in Kidney Diseases,with AKI grades of II-III;(4)All patients were treated with CVVH;and(5)Complete basic data were obtained for all patients.RESULTS The clinical effect of alprostadil administered in the treatment group was better than that observed in the control group(P<0.05).The urine output of patients in the alprostadil group returned to normal time(9.1±2.0 d)and was lower than that in the control group(10.6±2.5 d),the difference was statistically significant(P<0.05);adverse reactions occurred in the alprostadil group compared with the control group,but the difference was not statistically significant(P>0.05).CONCLUSION Alprostadil-assisted CVVH in the treatment of severely ill patients with AKI can effectively improve the renal resistance index and partial pressure of urine oxygen,and has a positive effect on improving renal function.

关 键 词：ALPROSTADIL Continuous venous-venous hemofiltration SEVERE Acute kidney injury 

分 类 号：R692[医药卫生—泌尿科学]