Gastrointestinal stromal tumor with multisegmental spinal metastases as first presentation:A case report and review of the literature  

作　　者：Yan Kong Xiao-Wei Ma Qian-Qian Zhang Yi Zhao He-Lin Feng 

机构地区：[1]Department of Medical Oncology,The Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,Hebei Province,China [2]Department of Orthopedics,The Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,Hebei Province,China [3]Department of Gynecology,Hebei Medical University Second Affiliated Hospital,Shijiazhuang 050000,Hebei Province,China

出　　处：《World Journal of Clinical Cases》2021年第6期1490-1498,共9页世界临床病例杂志

摘　　要：BACKGROUND Gastrointestinal stromal tumor(GIST)usually originates in the stomach,followed by the small intestine,rectum,and other parts of the gastrointestinal tract.The most common sites of metastasis are the liver and peritoneum,whereas spinal metastases from GIST are extremely rare.CASE SUMMARY We found a case of GIST with the first presentation of multilevel spinal metastases involving the thoracic and lumbar vertebrae.A 61-year-old Chinese man presented to our clinic because of pain in his lower back and hip for 10 d without cause.Subsequently,computed tomography(CT)and magnetic resonance imaging(MRI)revealed abnormal signals in the vertebral appendages of T12 and L4 accompanied by spinal canal stenosis,which was considered as tumor metastasis.As there were no metastases to vital organs,posterior thoracic and lumbar spinal decompression+adnexal mass resection+pedicle internal fixation was adopted to achieve local cure and prevent nerve compression.The results of histopathological studies were consistent with the metastasis of GIST.No local recurrence or new metastases were found at the 6-mo follow-up at the surgical site.The patient has no neurological symptoms at present.It is worth mentioning that a rectal mass was found and surgically removed 1 mo after the patient was discharged from hospital,and the pathological diagnosis of the mass was GIST.CONCLUSION By reviewing 26 previously reported cases of spinal metastasis in GIST,it was found that spinal metastasis of GIST has become more common in recent years,so the possibility of early spinal metastasis should be recognized.CT and MRI are of great value in the diagnosis of spinal metastatic tumors,and pathological biopsy is the gold standard for the diagnosis of metastatic tumors.It is safe and feasible to treat isolated spinal metastasis in GIST by excising metastatic masses,decompressing the spinal canal,and stabilizing the spine.

关 键 词：Spinal metastasectomy Gastrointestinal stromal tumor Multisegmental spinal metastases Magnetic resonance imaging Case report 

分 类 号：R735[医药卫生—肿瘤]