Epstein-Barr virus-positive diffuse large B-cell lymphoma with human immunodeficiency virus mimicking complicated frontal sinusitis:A case report  

作　　者：Seokho Yoon Kyeong Hwa Ryu Hye Jin Baek Hyo Jung An Yeon-Hee Joo 

机构地区：[1]Department of Nuclear Medicine and Molecular Imaging,Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital,Changwon 51472,South Korea [2]Department of Radiology,Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital,Changwon 51472,South Korea [3]Department of Radiology,Institute of Health Sciences,Gyeongsang National University School of Medicine,Jinju 52727,South Korea [4]Department of Pathology,Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital,Changwon 51472,South Korea [5]Department of Otorhinolaryngology,Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital,Changwon 51472,South Korea

出　　处：《World Journal of Clinical Cases》2021年第7期1654-1660,共7页世界临床病例杂志

摘　　要：BACKGROUND Primary non-Hodgkin’s lymphoma of the frontal sinus is extremely rare.In addition,Epstein-Barr virus(EBV)has been reported to play a role in the development of human immunodeficiency virus(HIV)-related malignant lymphomas.To the best of our knowledge,there is no report for the HIVassociated,EBV-positive primary diffuse large B-cell lymphoma(DLBCL)in the frontal sinus.CASE SUMMARY We present a unique case of HIV-associated,EBV-positive DLBCL in the frontal sinus in a 46-year-old man.Computed tomography of paranasal sinuses revealed dense opacification of the right frontal sinus with combined soft tissue swelling.Based on the clinical and radiological findings,the initial diagnosis was complicated frontal sinusitis,presenting Pott’s puffy tumor.Unexpectedly,HIV testing was positive on preoperative laboratory test,and the frontal sinus lesion was confirmed as EBV-positive DLBCL on biopsy.CONCLUSION Through this article,we suggest that EBV-positive DLBCL should be considered as possible diagnosis for patients with nonspecific space-occupying lesion of the paranasal sinuses.We also highlight an importance of clinical suspicion in diagnosing HIV infection because HIV serology is not routinely tested in patients with paranasal sinus problem.

关 键 词：LYMPHOMA Paranasal sinus Human immunodeficiency virus Epstein-Barr virus Computed tomography Case report 

分 类 号：R733.1[医药卫生—肿瘤]