Biodegradable magnesium alloy with eddy thermal effect for effective and accurate magnetic hyperthermia ablation of tumors  

作　　者：Nailin Yang Fei Gong Liang Cheng Huali Lei Wei Li Zongbin Sun Caifang Ni Zhanhui Wang Zhuang Liu 

机构地区：[1]Institute of Functional Nano&Soft Materials(FUNSOM),Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices,Soochow University,Suzhou 215123,China [2]Department of Vascular Surgery and Interventional Radiology,First Affiliated Hospital of Soochow University,Suzhou 215006,China [3]Luoyang Central Hospital affiliated to Zhengzhou University,Luoyang 471000,China

出　　处：《National Science Review》2021年第1期94-104,共11页国家科学评论（英文版）

基　　金：partially supported by the National Basic Research Programs of China(2016YFA0201200);the National Natural Science Foundation of China(51525203,51761145041and 51572180);the Collaborative Innovation Center of Suzhou Nano Science and Technology;the Jiangsu Natural Science Fund for Distinguished Young Scholars(BK20170063);Funded by the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions;supported by the Tang Scholarship of Soochow University。

摘　　要：Magnetic hyperthermia therapy(MHT)is able to ablate tumors using an alternating magnetic field(AMF)to heat up magnetocaloric agents(e.g.magnetic nanoparticles)administered into the tumors.For clinical applications,there is still a demand to find new magnetocaloric agents with strong AMF-induced heating performance and excellent biocompatibility.As a kind of biocompatible and biodegradable material,magnesium(Mg)and its alloys have been extensively used in the clinic as an implant metal.Herein,we discovered that the eddy thermal effect of the magnesium alloy(MgA)could be employed for MHT to effectively ablate tumors.Under low-field-intensity AMFs,Mg A rods could be rapidly heated,resulting in a temperature increase in nearby tissues.Such AMF-induced eddy thermal heating of MgA could not only be used to kill tumor cells in vitro,but also be employed for effective and accurate ablation of tumors in vivo.In addition to killing tumors in mice,we further demonstrated that VX2 tumors of much larger sizes growing in rabbits after implantation of Mg A rods could also be eliminated after exposure to an AMF,illustrating the ability of MgA-based MHT to kill large-sized tumors.Moreover,the implanted MgA rods showed excellent biocompatibility and~20%of their mass was degraded within three months.Our work thus discovered for the first time that non-magnetic biodegradable Mg A,an extensively used implant metal in clinic,could be used for effective magnetic thermal ablation of tumors under a low-field-intensity AMF.Such a strategy could be readily translated into clinical use.

关 键 词：magnesium alloy eddy thermal effect alternating magnetic field hyperthermia tumor ablation BIODEGRADATION 

分 类 号：R730.5[医药卫生—肿瘤] R318.08[医药卫生—临床医学]