In vitro study of enhanced photodynamic cancer cell killing effect by nanometer-thick gold nanosheets  

作　　者：Ziyi Zhang Dalong Ni Fei Wang Xin Yin Shreya Goel Lazarus NGerman Yizhan Wang Jun Li Weibo Cai Xudong Wang 

机构地区：[1]Department of Materials Science and Engineering,University of Wisconsin-Madison,Madison,Wisconsin,53706,USA [2]Department of Radiology,University of Wisconsin-Madison,Madison,Wisconsin,53705,USA [3]University of Wisconsin Carbone Cancer Center,Madison,Wisconsin,53705,USA

出　　处：《Nano Research》2020年第12期3217-3223,共7页纳米研究（英文版）

基　　金：This work was supported by the Army Research Office(No.W911NF-16-1-0198);the National Science Foundation(No.DMR-1709025);National Institutes of Health(Nos.R01EB0213360,1R21EB027857,and P30CA014520);Diffraction data was collected at ChemMatCARS Sector 15,which is principally supported by the Divisions of Chemistry and Materials Research,National Science Foundation,under grant number NSF/CHE-1834750;Use of the Advanced Photon Source,an Office of Science User Facility operated for the U.S.Department of Energy(DOE)Office of Science by Argonne National Laboratory,was supported by the U.S.DOE(No.DEAC02-06CH11357).

摘　　要：Photodynamic therapy(PDT)by near-infrared(NIR)irradiation is a promising technique for treating various cancers.Here,we reported the development of free-standing wafer-scale Au nanosheets(NSs)that exhibited an impressive PDT effect.The Au NSs were synthesized by ionic layer epitaxy at the air-water interface with a uniform thickness in the range from 2 to 8.5 nm.These Au NSs were found very effective in generating singlet oxygen under NIR irradiation.In vitro cellular study showed that the Au NSs had very low cytotoxicity and high PDT efficiency due to their uniform 2D morphology.Au NSs could kill cancer cells after 5 min NIR irradiation with little heat generation.This performance is comparable to using 10 times mass loading of Au nanoparticles(NPs).This work suggests that two-dimensional(2D)Au NSs could be a new type of biocompatible nanomaterial for PDT of cancer with an extraordinary photon conversion and cancer cell killing efficiency.

关 键 词：gold nanosheet ionic layer epitaxy surface plasmon photodynamic effect cancer therapy 

分 类 号：TB383[一般工业技术—材料科学与工程] R73[医药卫生—肿瘤]