hACE2转基因小鼠模型  

Human Angiotensin Converting Enzyme Two Transgenic Mice

作　　者：赵亚 师长宏 ZHAO Ya;SHI Changhong(Laboratory animal center,Air Force Medical University,Xi'an 710032,China)

机构地区：[1]空军军医大学实验动物中心,西安710032

出　　处：《实验动物科学》2020年第6期76-80,共5页Laboratory Animal Science

基　　金：军队实验动物专项课题(SYDW2017-004)。

摘　　要：血管紧张素转换酶2(angiotensin-converting enzyme 2,ACE2)是新型冠状病毒(severe acute respiratory syndrome coronavirus 2,SRAS-CoV-2)及SARS冠状病毒(severe scute respiratory syndrome coronavirus,SARS-CoV)的受体,也是新型冠状病毒的药物治疗及疫苗研发靶点。药物治疗及疫苗研发都离不开动物模型的支持,小鼠是目前各类疾病研究中应用最广泛的模型。早在2003年SARS冠状病毒来袭后,人们发现,由于小鼠与人的ACE2蛋白之间存在结构差异,造成冠状病毒对小鼠的感染率较低,为了更好研究冠状病毒的致病机理,国内外研究者建立了几种表达人源ACE2(h ACE2)的转基因小鼠模型。每种转基因小鼠由于应用技术、整合方式及小鼠品系等方面的差异,造成遗传背景及表型不同。本文重点对现有的各种h ACE2转基因小鼠模型进行介绍,利于研究者选择使用。Angiotensin-converting enzyme 2( ACE2) has been suggested to be the cellular receptor for 2019 novel coronavirus( 2019-nCoV). ACE2 is also a target for 2019-nCoV’s drug therapy and vaccine development. Drug therapy and vaccine research rely on the support of animal models,and mice is the most widely used model in all kinds of disease research. As early as the attack of SARS-CoV in 2003,researchers found that the infection rate of coronavirus to mice was low due to the structural differences between mouse and human ACE2 proteins. In order to better study the pathogenic mechanism of coronavirus,scientists have established several human ACE2( hACE2)transgenic mice. However,being their different application techniques,integration method and mouse strains these mice display different genetic background and different phenotypes. In this paper,we introduce different of hACE2 transgenic mice,which is beneficial to the follow-up research of the disease.

关 键 词：血管紧张素转换酶2 新型冠状病毒 动物模型 转基因小鼠 

分 类 号：R-332[医药卫生]