腹腔镜手术对早期卵巢癌患者疗效及应激反应的影响  

Effect of laparoscopic surgery on the efficacy and stress response of patients with early ovarian cancer

作　　者：王佳 王卉佳 付谨 WANG Jia;WANG Huijia;FU Jin(Department of Obstetrics and Gynecology,Zhumadian Traditional Chinese Medicine Hospital,Zhumadian 463000,He’nan,China;Department of Dermatology,Zhumadian Traditional Chinese Medicine Hospital,Zhumadian 463000,He’nan,China)

机构地区：[1]驻马店市中医院妇产科,河南驻马店463000 [2]驻马店市中医院门诊皮肤科,河南驻马店463000

出　　处：《癌症进展》2021年第2期183-185,206,共4页Oncology Progress

摘　　要：目的探讨腹腔镜手术对早期卵巢癌患者疗效及应激反应的影响。方法依据手术方式将140例卵巢癌患者分为观察组和对照组,每组70例,对照组患者接受开腹肿瘤细胞减灭术治疗,观察组患者接受腹腔镜肿瘤细胞减灭术治疗。比较两组患者的手术相关指标、手术前后应激反应指标[皮质醇、促肾上腺皮质激素(ACTH)及肾上腺素]水平、并发症发生情况、随访20个月的短期疗效及肿瘤复发情况。结果观察组患者手术时间、肠道恢复时间、手术切口长度和住院时间均明显短于对照组患者,术中出血量明显低于对照组患者,差异均有统计学意义(P﹤0.01)。术后,两组患者皮质醇、ACTH及肾上腺素水平均高于本组术前,且观察组患者皮质醇、ACTH及肾上腺素水平均低于对照组患者,差异均有统计学意义(P﹤0.05)。两组患者并发症发生率、生存率和复发率比较,差异均无统计学意义(P﹥0.05)。结论腹腔镜肿瘤细胞减灭术治疗早期卵巢癌患者短期疗效较好,且手术创伤小,对患者应激刺激较小,有助于患者的术后恢复。Objective To investigate the effect of laparoscopic surgery on the efficacy and stress response of patients with early ovarian cancer.Method According to the difference of operation methods,140 patients were divided into observation and control group,70 cases in each group.In the observation group,hand assisted laparoscopic ovanan cancer cell reduction was used,while in the control group,laparotomy was used.The surgical-related indicators,levels of stress response indicators[cortisol,adrenocorticotropic hormone(ACTH)and epmephrine]before and after the operation,the occurrence of complications,the short-term efficacy and tumor recurrence of the two groups were compared.Result The operation time,bowel recovery time,surgical incision length and hospital stay of the observation group were significantly shorter than those of the control group,and the amount of intraoperative blood loss was significantly lower than that of the control group,the differences were statistically significant(P<0.01).After operation,the levels of cortisol,ACTH and epinephrine of the two groups of patients were higher than those of this group,and the levels of cortisol,ACTH,and epinephrine of the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).There was no statistically significant difference in the complication rate,survival rate and recurrence rate between the two groups of patients(P>0.05).Conclusion Laparoscopic cytoreductive surgery has a good short-term effect in the treatment of patients with early ovarian cancer,and has less surgical trauma,less stress to the patient,and helps the patient to recover after surgery.

关 键 词：卵巢癌 腹腔镜 肿瘤细胞减灭术 应激反应 并发症 疗效 

分 类 号：R737.31[医药卫生—肿瘤]