Controlled synthesis of polypeptides  

作　　者：Yang Liu Di Li Jianxun Ding Xuesi Chen 

机构地区：[1]Key Laboratory of Polymer Ecomaterials,Chanigchun ltstitute of Applied Chemistry,Chinese Academy of Sciences,Changchun 13002,China [2]University of Science and Technology of China,Hefei 230026,China [3]Jilint Biomedical Polymers Engineering Laboratory,Changchur 130022,China

出　　处：《Chinese Chemical Letters》2020年第12期3001-3014,共14页中国化学快报（英文版）

基　　金：the financial support from the National Natural Science Foundation of China(Nos.51973216,51873207,51803006,51833010,51673190 and 51520105004);the Science and Technology Development Program of Jilin Province(No.20190201068JC);the National Key Research and Development Program of China(No.2016YFC1100701);the Youth Talents Promotion Project of Jilin Province(No.181909);the Youth Innovation Promotion Association of Chinese Academy of Sciences(No.2019005)。

摘　　要：Polypeptides are one kind of promising biodegradable and biocompatible biomedical polymers with the structural units of various a-amino acids.Polypeptides were first polymerized by the ring-opening polymerization(ROP)of α-amino acid N-carboxyanhydrides(NCAs)by Leuchs and Hermann in 1906.In the past decades,several effective strategies,including the selection of initiators,the adjustment of reaction conditions,and the introduction of catalysts,have been reported to improve the controllability of the ROP of various a-amino acid NCAs to synthesize different polypeptides with precise chemical structures and low polydispersity indexes.In this Review,the strategies,mechanisms,challenges,and opportunities for controlled synthesis of polypeptides by the ROP of differentα-amino acid NCAs have been declared.

关 键 词：α-Amino acid N-carboxyanhydride Ring-opening polymerization Controlled synthesis POLYPEPTIDE Biomedical application 

分 类 号：R318.08[医药卫生—生物医学工程] TQ936.16[医药卫生—基础医学]