LHRH/TAT dual peptides-conjugated polymeric vesicles for PTT enhanced chemotherapy to overcome hepatocellular carcinoma  

作　　者：Yu Qin Qing Guo Shengjie Wu Chenlu Huang Zhiming Zhang Li Zhang Linhua Zhang Dunwan Zhu 

机构地区：[1]Tianjin Key Laboratory of Biomedical Materials,Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy,Institute of Biomedical Engineering,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin 300192,China

出　　处：《Chinese Chemical Letters》2020年第12期3121-3126,共6页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(Nos.81671806,81571793);CAMS Initiative for Innovative Medicine(Nos.2017-I2M-4-001,2017-I2M-3-020);Fundamental Re search Funds for the Central Universities(Nos.2019PT320028,2019-0831-03)。

摘　　要：Combination therapy such as photothermal therapy(PTT)enhanced chemotherapy is regarded as a promising strategy for cancer treatment.Herein,we developed redox-responsive polymeric vesicles based on the amphiphilic triblock copolymer PCL-ss-PEG-ss-PCL.To avoid the limited therapeutic effect of chemotherapeutic drugs caused by systemic exposures and drug resistance,the redox-sensitive polymeric vesicles were cargoed with two chemotherapeutics:doxorubicin(DOX)and paclitaxel(PTX).Besides,indocyanine green(ICG)was encapsulated,and cell-penetrating peptides and LHRH targeting molecule were modified on the surface of polymeric vesicles.The results indicated that the polymeric vesicles can load different kinds of drugs with high drug loading content,trigger drug release in responsive to the reductive environment,realize high cellular uptake via dual peptides and laser irradiation,and achieve higher cytotoxicity via chemo-photothermal combination therapy.Hence,the redox-responsive LHRH/TAT dual peptides-conjugated PTX/DOX/ICG co-loaded polymeric micelles exhibited great potential in tumor-targeting and chemo-photothermal therapy.

关 键 词：Redox-responsive Polymeric vesicles CHEMOTHERAPY Photothermal therapy Combination therapy 

分 类 号：R735.7[医药卫生—肿瘤] TQ317[医药卫生—临床医学]