肝癌患者微创介入治疗对血清ALT水平、T细胞免疫功能的影响  

Impacts of minimally invasive interventional therapy on serum ALT level and T cell immune function in patients with liver cancer

作　　者：杨嘉文 YANG Jiawen(Department of Oncology,Foshan Sanshui District People's Hospital in Guangdong Province,Foshan 528100,China)

机构地区：[1]广东省佛山市三水区人民医院肿瘤科,广东佛山528100

出　　处：《中国现代医生》2021年第1期77-80,共4页China Modern Doctor

摘　　要：目的研究肝癌患者行微创介入治疗对血清ALT水平、T细胞免疫功能的影响。方法选择2018年1月至2019年12月我院收治的80例肝癌患者,按照随机数字表法分为观察组与对照组各40例,观察组行微波消融术治疗,对照组行肝动脉栓塞术治疗,比较两组肝功能、T细胞免疫功能、血清Th1型细胞因子含量。结果术前比较两组肝功能无差异、术后两组比较AST值无差异(P>0.05);术后观察组ALT值较对照组高,差异有统计学意义(P<0.05);术前比较两组T细胞免疫功能无差异(P>0.05);术后观察组CD3^(+)、CD4^(+)及CD4^(+)/CD8^(+)值较对照组高,CD8^(+)值较对照组低,差异有统计学意义(P<0.05);术前两组血清Th1型细胞因子无差异(P>0.05);术后观察组IL-2为(102.24±9.42)pg/mL、TNF-α为(80.54±6.43)pg/mL及IFN-γ为(58.83±8.46)pg/mL指标高于对照组[(90.38±1.25)pg/mL、(71.42±7.56)pg/mL、(51.45±8.43)pg/mL],差异有统计学意义(P<0.05)。结论微波消融术治疗肝癌患者能提高整体疗效、稳定病情。Objective To research the impacts of minimally invasive interventional therapy on serum ALT level and T cell immune function in patients with liver cancer.Methods A total of 80 patients with liver cancer admitted to our hospital from January 2018 to December 2019 were divided into the observation group(n=40)and the control group(n=40)according to the random number table method.The observation group was treated with microwave ablation,while the control group was treated with hepatic artery embolization.The hepatic function,T cell immune function and serum Th1 type cytokines were compared between the two groups.Results There were no differences in hepatic function between the two groups before operation and AST value between the two groups after operation(P>0.05).The ALT value of the observation group was higher than that of the control group after operation,with statistically significant difference(P<0.05).There was no difference in T cell immune function between the two groups before operation(P>0.05).After operation,the values of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the observation group were higher than those in the control group,and the CD8^(+)value was lower than that in the control group,with statistically significant differences(P<0.05).There was no difference in serum Th1 type cytokines between the two groups before operation(P>0.05).The levels of IL-2 was(102.24±9.42)pg/mL,TNF-αwas(80.54±6.43)pg/mL and IFN-γwas(58.83±8.46)pg/mL after operation in the observation group were higher than(90.38±1.25)pg/mL,(71.42±7.56)pg/mL and(51.45±8.43)pg/mL in the control group respectively,with statistically significant differences(P<0.05).Conclusion Microwave ablation can improve the overall therapeutic efficacy and stabilize the condition of patients with liver cancer.

关 键 词：肝癌 微创介入 血清ALT水平 T细胞免疫 TH1型细胞因子 

分 类 号：R735.7[医药卫生—肿瘤]