降钙素原与中性粒细胞碱性磷酸酶在急性脑出血患者手术前后的临床意义  

The Clinical Significance of Procalcitonin and Neutrophil Alkaline Phosphatase Before and After Surgery in Patients with Acute Cerebral Hemorrhage

作　　者：应国明 张云玉 高美华 Ying Guoming;Zhang Yunyu;Gao Meihua(People's Hospital of Poyang County,Jiangxi Province,Poyang Jiangxi 333100,China)

机构地区：[1]江西省鄱阳县人民医院,江西鄱阳333100

出　　处：《医疗装备》2021年第3期4-5,共2页Medical Equipment

基　　金：江西省卫生计生委科技计划(20187295)。

摘　　要：目的分析降钙素原(PCT)与中性粒细胞碱性磷酸酶(NAP)在急性脑出血患者手术前后的临床意义。方法选择2018年3月至2020年2月医院收治的66例急性脑出血患者作为研究对象,将术后出现感染的患者纳入感染组(35例),将术后未出现感染的患者纳入非感染组(31例),比较两组PCT水平和NAP积分,并分析感染组PCT水平和NAP积分的相关性及两者的诊断性能(特异度、灵敏度)。结果手术后3 h,两组PCT水平和NAP积分均高于手术前1 d,且感染组高于非感染组,差异有统计学意义(P<0.05);经Pearson相关性分析,感染组PCT水平和NAP积分成正相关(R~2=0.067,P=0.026)。在诊断感染时,PCT和NAP的ROC曲线下面积分别为0.836和0.869;PCT和NAP的临界值分别为6.18 ng/L和85.2分时,诊断特异度分别为90.19%和90.47%,诊断灵敏度分别为84.52%和83.79%。结论 PCT和NAP可作为诊断急性脑出血患者手术后感染的有效指标。Objective The clinical significance of procalcitonin(PCT)and neutrophil alkaline phosphatase(NAP)in patients with acute cerebral hemorrhage before and after operation was analyzed.Methods 66 patients with acute cerebral hemorrhage admitted to the hospital from March 2018 to February 2020 were selected as the research objects in this study.The patients with postoperative infection were included in the infection group(35 cases),while the patients without postoperative infection were included in the non-infection group(31 cases).The levels of PCT and scores of NAP between the two groups were compared,and the correlation coefficient and diagnostic performance(specificity and sensitivity)of PCT and NAP in the infection group were analyzed.Results 3 hours after operation,the levels of PCT and scores of NAP in the two groups were both higher than those of 1 day before operation,and the levels of PCT and scores of NAP in the infected group were higher than those in the non-infected group,the differences were statistically significant(P<0.05).According to the results of Pearson correlation analysis,the levels of PCT in the infected group was positively correlated with the scores of NAP(R=0.768,P=0.026).In the diagnosis of infection,the areas under the ROC curve of PCT and NAP were 0.836 and 0.869,respectively.When the critical values of PCT and NAP were 6.18 mg/L and 85.2,the diagnostic specificity were 90.19%and 90.47%,and the diagnostic sensitivity were 84.52%and 83.79%.Conclusion PCT and NAP could be regarded as effective indicators to detect postoperative infection in patients with acute cerebral hemorrhage.

关 键 词：降钙素原 中性粒细胞碱性磷酸酶 急性脑出血 

分 类 号：R74[医药卫生—神经病学与精神病学]