Cortical Astrocyte-neuronal Metabolic Coupling Emerges as a Critical Modulator of Stress-induced Hopelessness  

作　　者：Giannina Descalzi 

机构地区：[1]Department of Biomedical Sciences,Ontario Veterinary College,University of Guelph,Guelph,ON NIG 2W1,Canada

出　　处：《Neuroscience Bulletin》2021年第1期132-134,共3页神经科学通报（英文版）

摘　　要：Stress is a major risk factor for the development of mental illness,such as major depression disorder (MDD)[1].Despite decades of progress,including findings that stressinduced depression corresponds with numerous morphological and functional neuronal changes within brain structures associated with cognition and mood,such as the medial prefrontal cortex (mPFC)[1-3],a thorough understanding of how stress induces the core symptoms of depression,such as hopelessness,is still lacking.In an exciting new paper in mice,Yin et al.show that astrocyteneuronal metabolic coupling in the mPFC is critically involved in the stress-induced passive coping response in mice [4].

关 键 词：PFC Cortical Astrocyte-neuronal Metabolic Coupling Emerges as a Critical Modulator of Stress-induced Hopelessness 

分 类 号：R749[医药卫生—神经病学与精神病学]