高脂饲料诱导代谢性疾病动物模型  

Metabolic Disease Animal Models induced by High-fat Diets

作　　者：罗建波 李军晖 王海江[1] 周小玉 曾涛[1] 周佳 朱献军[2] LUO Jianbo;LI Junhui;WANG Haijiang;ZHOU Xiaoyu;ZENG Tao;ZHOU Jia;ZHU Xianjun(Institute of Laboratory Animal Sciences,Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital,Chengdu 610212,China;Sichuan Provincial Key Laboratory for Human Disease Gene Study,Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital,Chengdu 610072,China)

机构地区：[1]四川省医学科学院·四川省人民医院实验动物研究所,成都610212 [2]四川省医学科学院·四川省人民医院人类疾病基因研究四川省重点实验室,成都610072

出　　处：《实验动物与比较医学》2021年第1期70-78,共9页Laboratory Animal and Comparative Medicine

基　　金：实验动物代谢性疾病模型饲料的开发与应用(2018YSZH0026)。

摘　　要：采用饲喂高脂饲料的方式造成动物代谢异常,此法常被用来探索疾病的发生、发展规律,为临床研究提供理论依据。本文综述了常用高脂饲料诱导的代谢性疾病动物模型,并探讨疾病模型形成机制及各营养成分的作用方式,为相关研究人员建立疾病模型时提供理论和实践参考。High-fat diets are often used to induce models with nutritional abnormalities and stimulate human diseases,which are used to explore the mechanism of disease development and widely used in clinical hypothesis study.In order to provide theoretical and practical basis for researchers in this field,recent advances on animal models of metabolic diseases induced by high-fat diets were reviewed,and the mechanisms underlying disease development and the respective roles of nutrient components of the diets were also discussed.

关 键 词：高脂饲料 代谢性疾病 动物模型 作用机制 

分 类 号：Q95-33[生物学—动物学] R-332[医药卫生]