早发冠心病相关脂质代谢基因变异的研究进展  

Research progress of the genetic variations in lipid metabolism related with premature coronary heart disease

作　　者：彭琴 周琴怡 黄柯 马小峰[1] 姜志胜[2] PENG Qin;ZHOU Qinyi;HUANG Ke;MA Xiaofeng;JIANG Zhisheng(Cardiovasology Department,Nanhua Hospital Affiliated to University of South China,Hengyang,Hunan 421002,China;Institute of Cardiovascular Disease&Key Laboratory for Arteriosclerology of Hunan Province&International Laboratory for Scientific Innovation and Co-operation of Hunan Province,University of South China,Hengyang,Hunan 421001,China)

机构地区：[1]南华大学附属南华医院心血管内科,湖南省衡阳市421002 [2]南华大学心血管疾病研究所动脉硬化学湖南省重点实验室湖南省动脉硬化性疾病国际科技创新合作基地,湖南省衡阳市421001

出　　处：《中国动脉硬化杂志》2021年第3期264-270,共7页Chinese Journal of Arteriosclerosis

基　　金：2020年湖南省科技厅重点研发项目(2020SK2105);湖南省卫生健康委2020年重点指导课题(20201905)。

摘　　要：早发冠心病(pCHD)是冠心病的一种特殊临床类型。最新的研究表明,pCHD具有很强的遗传基础,遗传因素约占pCHD发病的50%~60%,其中以脂质代谢基因最为重要。脂质代谢基因变异可导致脂质合成及代谢障碍,并出现以动脉粥样硬化(As)及pCHD为临床特征的一系列疾病。该文旨在对脂质代谢基因变异与pCHD之间的关系进行综述。Premature coronary heart disease(pCHD)is a special type of cardiovascular disease.Recent research has demonstrated that pCHD possesses a strong genetic basis,genetic factors account for almost 50%~60%morbidity rate of pCHD,and lipid metabolism gene plays the most important role in it.Genetic variations of lipid metabolism can lead to the impediment of lipid synthesis and catabolism,as well as a series of disease characterized by atherosclerosis(As)and pCHD.This review aims to give a brief summary of the relationship between the genetic variations of lipid metabolism and pCHD.

关 键 词：早发冠心病 动脉粥样硬化 脂质代谢 基因变异 

分 类 号：R54[医药卫生—心血管疾病]