铁死亡在眼科疾病中的应用研究进展  

Application of ferroptosis in ophthalmic diseases

作　　者：田渼雯 秦波[3] 刘身文[2] TIAN Meiwen;QIN Bo;LIU Shenwen(The Second Clinical Medical College of Jinan University,Shenzhen 518000,Guangdong Province,China;Department of Ocular Trauma,Shenzhen Eye Hospital,Shenzhen 518000,Guangdong Province,China;Department of Ocular Trauma,Shenzhen Aier Eye Hospital Affiliated to Jinan University,Shenzhen 518032,Guangdong Province,China)

机构地区：[1]暨南大学第二临床医学院,广东省深圳市518000 [2]暨南大学附属深圳眼科医院眼外伤科,518000广东省深圳市 [3]暨南大学深圳爱尔眼科医院眼外伤科,广东省深圳市518032

出　　处：《眼科新进展》2021年第2期182-188,共7页Recent Advances in Ophthalmology

基　　金：广东省科技计划公益研究与能力建设项目(编号2017A020211028);深圳市科技计划项目(编号JCYJ20180228164300106)。

摘　　要：铁死亡是一种特殊类型的细胞死亡方式,其为依赖铁元素代谢紊乱,并以细胞内胞质和脂质的活性氧堆积为特征的调节性细胞死亡。本文综述了铁死亡概念的发展、铁死亡的机制及其在眼科疾病中的最新研究进展,包括角膜上皮、视网膜色素上皮细胞、糖尿病视网膜病变、视网膜缺血-再灌注损伤、青光眼、视网膜母细胞瘤、视网膜色素变性等,为临床上眼科医师对疾病的研究和防治开辟新的途径。Ferroptosis which is an iron-dependent regulating cell death characterized by intracellular reactive oxygen species is a newly discovered form of cell death.In this paper,we summarized the development of the concept of ferroptosis,the mechanism of ferroptosis,and the latest research progress in ophthalmic applications which mainly in corneal diseases,retina pigment epithelium,diabetic retinopathy,retinal ischemia reperfusion injury,glaucoma,retinoblastoma and retinitis pigmentosa.The mechanism of the role of ferroptosis in the above-mentioned ophthalmic diseases is discussed,opening up new ways for the research and prevention of clinical ophthalmic diseases.

关 键 词：铁死亡 角膜上皮细胞 视网膜色素上皮细胞 糖尿病视网膜病变 视网膜缺血-再灌注损伤 青光眼 视网膜色素变性 

分 类 号：R77[医药卫生—眼科]